Renal Flashcards

1
Q

Kidney sense hypoxia

A

Interstitial cells in peritubal caps secrete epo which stim rbc form in bone marrow, get increase o2 capacity

-epo sup inc harmonic kidney disease

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2
Q

Calcidiol to calcitriol

A

Proximal convoluted tubule via 1 a hydroxylase

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3
Q

Prostagladin

A

From paracrine cells, vasodilator afferent arterioles and increase filtration of blood

Renal protective

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4
Q

NSAIDs

A

Block prostaglandins get constriction afferent arterioles and decrease and gfr in low blood flow get renal failure

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5
Q

Dopamine

A

Proximal convoluted tube
Promotes natriuretic
Dilated arterioles
Increases glomerular filtration

At high doses vasoconstriction

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6
Q

Coma, malaise nausea and stupendous state seizures

A

Low sodium

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7
Q

Bradycardia, decreased DTN, hypotension with cardiac arrest, hypocalcemia

A

Increase mg

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8
Q

Arrhythmias, muscle weakness, widened qrs, peaked t waves

A

Potassium high

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9
Q

Twitching, tetany, seizures, prolonged qt

A

Low calcium

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10
Q

Bone low, osteomalacia, rickets

A

Low phosphate

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11
Q

Too much phosphate

A

Hypocalcemia, kidney stones

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12
Q

Flattened u wave t wave, arrhythmias, muscle cramps, weak

A

Low k

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13
Q

Kidney stones, abdominal pain, increased urinary frequency, anxiety, altered mental status

A

Elevated calcium

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14
Q

Elevated calcium

A

Stones, bones, groans, thrones, psychiatric overtones

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15
Q

Tetany, torsades, hypokalemia, hypocalcemia

A

Magnesium low

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16
Q

Uti presentation

A

Suprapubic pain

Dysuria

Increased urgency

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17
Q

Who gets uti

A

Women, diabetes, indwelling catheter, intercoarse

18
Q

What causes uti

A

E. coli, klebsiella, proteus mirabilis-ammonia scent

-staph saphorphiticus

19
Q

UA UTI

A

Nitrites-gram negative orgamins

Leukocytes

20
Q

WBC UA but grow nothin in culture

A

Won’t grow gonorrhea of chlamydia so keep going

21
Q

Coca Cola urine, subepithelial humps, positice anti dnase b , high streptolysin O titer

A

Post streptococcal glomerulonephritis

22
Q

Streptolysin o titer

A

Group a strep-strep throat or impetigo

23
Q

May occur after URI, purpura butt and leg, Berger disease igA

A

Iga nephropathy-henosch purpura

24
Q

Defect in type IV collagen, cataracts, hematuria, high frequency hearing loss

A

Alport

25
Q

Granulomas in nasal passage, pulmonary infiltrates, hematureia, positive cANCA

A

Granulomatous with polyangitis

Wagner lung and kidney

26
Q

Involves nasal passages, associated with asthma, positive pANCA, peripheral eosinophilia

A

Eosinophilic granulomatosis with polyangitis

27
Q

Microscopic hematuria, pulmonary infiltrates, type II hypersensitivity, anti GBM antibodies

A

Good pasture

28
Q

Acute intestinal nephritis

A

Acute inflammation of interstitial of the kidneys

Leads to edema of the kidneys, damaged tubules, and azotemia

Urinalysis shows increased WBC no nitrates

Urine smear-eosinophils

29
Q

What cause acute interstitial nephritis

A

Diuretics, penicillin, PPI, sulfa, rifampin, NSAIDS

30
Q

P

A
Pee(diuretics
Pain fre (nsaids)
Penicillins and cePhalosporins
PPI 
Rifampin
31
Q

How

A

Enter basement membrane act as hapten to stimulate immune response

32
Q

Acute intestinal nephritis presentation

A

Asymptomatic, fever, rash, costovertebral tenderness, hematuria

Key is UA

33
Q

Sulfonamide lop diuretics

A

Furosemide, bumetanide, torsemide

34
Q

MOA sulfonamide loop diuretics

A

Inhibit NaK CL

Ruin hypertonicity of medulla, make urine dilute, stimulate prostagladin E(dilate afferent)

Increase urine output

35
Q

Who give

A

Cirrhosis, HF, nephrotic syndrome, pulmonary edema, hypercalcemia

36
Q

Risk loop

A

Ototoxicity, hypokalemia, hypomagnesia, dehydration, metabolic alkalosis, nephritis, gout, allergy

OH DANG

37
Q

Ethacrynic acid

A

Inhibit Na K Cl in TAL
No sulfa

Ototoxicity

38
Q

Loop earrings hurt your ears

A

Ok

39
Q

Thiazides

A

Hydrochlorothiazide,

Chlorthalidone

Metolazone

40
Q

MOA thiazides

A

Salt not reabsorbed follows

Decrease calcium excretion

Use thiazides for HTN
Idiopathic hypercalciuria
Nephrogenic DI

41
Q

AE thiazide

A

Hypokalemia metabolic alkalosis, hyponatremia, sulfa

Hyperglycemia, lipidemia, uric Emma, calcemia