Renal Flashcards
Nephron with glomeruli located in
Outer cortex of kidney
Exretion rate (ER) =
(filtration rate - reabsorption rate) + secretion rate
Essential HT increases renal artery P leading to
Vasoconstriction of afferent
Vasodilation of efferent
Constriction of efferent a causes
Increase Glomerular Cap P
Decrease Peritubular Cap P
Decrease Nephron Plasma flow
Dilation of efferent A causes
Decrease Glomerular Cap P
Increase Peritubular Cap P
Increase Nephron Plasma Flow
Constriction of afferent A causes
Decrease Glomerular Cap P
Decrease Peritubular Cap P
Decrease Nephron Plasma flow
Dilation of afferent A causes
Increase Glomerular Cap P
Increase Peritubular Cap P
Increase Nephron Plasma flow
Normal GFR is
120 mL/min
Normal RPF is
600 mL/min
Filtration Fraction (FF)=
GFR/RPF
120/600
.20 or 20%
The greater FF the…
The higher the oncotic pressure in the peritubular capillaries
Afferent contriction affect on GFR, RPF, FF, and Glomerular filtration pressure
- GFR: Decrease
- RPF: Decrease
- FF: Normal
- glomerular filtration P: Decrease
Efferent constriction affect on GFR, RPF, FF, and Glomerular Filtration P
- GFR: Increase
- RPF: Decrease
- FF: Increase
- Glomerular Filtration P: Increase
Affect of Angtiotensin 2 on arterioles
Constricts both afferent and efferent but has a bigger effect on efferent
What are the consequences of Angiotensin 2
- Decrease RPF
- Increase GFR
- Increase FF
- Increase forces promoting reabsorption in the peritubular capillaries
Filtered load=
GFR X Px
Excretion=
Ux X V
What substances net reabsorption
Glucose
Sodium
Urea
What substances net secretion
PAH
Creatine
What substnaces have excretion = filtration
Inulin
Mannitol
Net transport rate=
Filtered load - Excretion rate
(GFR X Px) - (Ux X V)
Clearnace of x=
(Ux X V)/Px
Proximal Renal Tubular Acidosis (Type 2) is due to
A diminished capacity of the proximal tubule to reabsorb bicarbonate
Distal Renal Tubular Acidosis (Type 1) is due to
Inability of the distal nephron to secrete and excrete fixed acids
Affect of acidosis on K
Shits K from the ICF to ECF
Decreased intracellular K reduces the K gradient causing a decreas in K secretion
What causes prerenal ARF
Things that decrease renal perfusion pressure:
- Hypovolumia of hemorrhage
- Diarrhea
- Vomiting
- CHF
