Regulators of exercise metabolism during intense exercise Flashcards
What is regarded as the ‘gross controller’ of metabolic processes?
Calcium
What is ‘protein kinase’?
A protein which adds a phosphate to another protein to change its function
What is the creatine-phosphate system equation, and what enzyme is this reaction regulated by?
PCr + ADP + H+ = ATP + creatine
- Regulated by creatine kinase
What enzyme breaks glycogen down to glucose-1-phosphate?
Glycogen phosphorylase
How is glycogen phosphorylase regulated?
Epinephrine and Ca2+ activate phosphorylase kinase, which phosphorylates (activates) phosphorylase b to glycogen phosphorylase via covalent regulation.
How do ADP, AMP and Pi regulate glycogen phosphorylase?
Allosteric regulation
Why is glycogen phosphorylase considered a ‘non equilibrium enzyme’?
Because it is controlled by external factors
What enzyme catalyses the breakdown of fructose-6-phosphate?
Phosphofructokinase (PFK)
How is PFK stimulated?
By products of ATP hydrolysis, via allosteric regulation.
It’s substrate (fructose-6-phosphate) also activates PFK.
What is the primary importance of lactate?
To regenerate NAD+
