Regulation of the adaptive immune response Flashcards
What is tolerance?
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Where does central tolerance occur?
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What are the differences between B and T cell central tolerance?
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Why are these differences important?
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Define negative and positive selection and know why each is important.
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What is peripheral tolerance and how does it differ from central tolerance?
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What role does somatic hypermutation play in peripheral tolerance?
a
What does the term “leaky” have to do with tolerance?
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What is a cryptic antigen?
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What is an immunologically privileged site? Name 3.
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How are cryptic antigens seen by the immune system?
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List several ways to achieve peripheral tolerance.
T cells? B cells?
aa
Why is it necessary to regulate the peripheral immune responses?
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List four mechanisms of regulation of the peripheral adaptive immune response.
a
List one difference between natural and adaptive Treg.
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What are the mechanisms that Treg cells suppress the response of other T or B cells?
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What roles do IL-10 and TGF-beta play in the immune regulation?
a
What is autoimmunity?
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What are the mechanisms of “breaking” tolerance?
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Explain molecular mimicry.
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Why is autoimmunity linked to certain haplotypes?
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