MHC and TCRs/BCRs in antigen recognition Flashcards
Understand importance of polymorphism, polygeny and co-dominance.
93
Know what heterozygote advantage is and its affect on disease
93
Understand the different functions of MHC class I and class II
a
Understand the differences in peptides that are presented in MHC I and MHC II
a
Know the cells that present MHC I and MHC II
a
Know the cells that are activated by MHC I and MHC II
a
Understand the function of genes in MHC class III
94
Understand MHC restriction
a
Know the definition of superantigen
a
Know the structure of the TCR complex
a
Understand co-receptors.
a
Know the molecules involved in adherence and interactions
a
Understand “first signal” and “second signal”
a
Understand what signals result in tolerance
a
Understand Th1 vs Th2 with important cytokines
98
Understand differences of alpha-beta and gamma-delta TCR
95
Know where the change from Pre-B cell to naive B cell takes place
a
Know where activation of immature B cells takes place
a
What happens to the B cell when it is activated?
a
Understand mature B cells/plasma cells
a
What structures combine to make a functional BCR?
a
What molecules and particular domains are responsible for signaling to the nucleus?
a
Know alternate methods of antigen recognition by the B cell
a
Understand processing of antigen in the B cell
a
