Regulation of synaptic transmission Lec 9

Question 1

Lambert-Eaton myasthenic syndrome (LEMS)

Answer 1

Autoimmune Dz in cancer pts
Skeletal muscle weakness and fatigue
Reduction in Ach release
Loss of Ca channels in presynaptic terminal

Question 2

Synaptic faciliation

Answer 2

Ca entry is fast
Ca clearance not so much
Ca builds up
-increase in synaptic strength

Question 3

Glutamate

Answer 3

Major excitatory transmitter in the brain
AMPA- fast EPSP via flow of Na and K
NMDA- Slow EPSP via flow of Na, K and Ca
-blocked by Mg

Question 4

CREB

Answer 4

Signaling pathways converge by activating kinases that phosphorylate CREB
Phosphorylation
-allows binding of co-activators
-stimulates RNA pol to begin RNA synthesis

Question 5

GABA

Answer 5

Major inhibitory transmitter in brain

Hyperpolarization IPSPs

Question 6

GABAa

Answer 6

fast IPSP via flow of Cl ions

Phenobarb- increase the channel open time when GABA present

Question 7

GABAb

Answer 7

slow IPSP

G-protien

Question 8

Phenobarbital

Answer 8

Elicits much larger IPSP

increase the channel open time when GABA present