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Neuro U3 > Clinical Epilepsy lec 10 > Flashcards

Clinical Epilepsy lec 10 Flashcards

1
Q

Aura

A

Brief and simple seizure

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2
Q

Prodrome

A

combination of symptoms

not seizure

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3
Q

Ictal

A

Clinical feature of seizure

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4
Q

Interictal

A

Btwn two seizures

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5
Q

Post-ictal

A

symptoms after seizure is over

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6
Q

Partial (focal)

A

Start in one area of the brain

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7
Q

Simple partial

A

no loss of consciousness

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8
Q

Complex partial

A

impaired consciousness

Do not remember

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9
Q

Secondary Generalized

A

Partial can spread

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10
Q

Generalized

A

Usually start in thalamus and project to cortex

Both hemispheres

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11
Q

Convulsive

A

Repeated motorized activity

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12
Q

Non-convulsive

A

Firing but no convulsions

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13
Q

Epileptic syndrome

A

Dz of brain characterized by enduring predisposition to generate epileptic seizures

  • idiopathic
  • Symptomatic- consequence of a know or suspected disorder of CNS
  • cryptogenic
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14
Q

Mutation in Nav1.1

A

GEFS+

  • milder than SMEI
  • usually no cognitive impairment
  • Loss of fxn of fast inactivation
    - gain of fxn of Na channel
    - persistent Na current
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15
Q

SMEI (darvent syndrome)

A

Reduction of Na channel density

Loss of high freq AP

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16
Q

Loss of inhibitory fan of GABAergic Purkinje cells

A

Cerebellum

Ataxia

17
Q

Loss of inhibitory GABAergic interneurons

A

More firing of AP

Seizures

18
Q

Tigabine

A

Decrease reuptake of GABA

19
Q

Benzodiazepines (clonazepam)

A

Increase in response of post-synaptic GABA Receptors

20
Q

SMEI clinical manifestation

A 
1st year- seizures associated with elevated temp
-progressively prolonged and cluster
2nd year- Psychomotor delay
-ataxia
-cognitive impairment
21
Q

Febrile seizures

A

Seizures occurring after 1 month of age

  • associated with febrile illness
  • Mutation in Nav1.1 may be cause in many pts
  • reduction of peak Na currents
22
Q

K channelopathies

A

Missense mutation
LOF
Benign familial neonatal convulsion (BFNC)
resolves by 6 weeks

23
Q

T-type Ca channelopathies

A

GOF
Mostly in thalamic cells
Excessive synchronous rhythmic burst firing
idiopathic generalized epilepsy

24
Q

Cl channelopathies

A

Cl channels responsible for GABAergic synapse hyperpol

Can lead to idiopathic generalized epilepsy

25
Q

Antiepileptic Drugs (AED)

A

Decrease the hyper excitability of neurons
-Na channel blockers
Increasing the inhibitory fxn of neurons
-GABAergic medication

26
Q

Surgery

A

May be considered in localization related epilepsy that is medically refractory- fail to respond to 2 meds

Neuro U3 (17 decks)

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