regulation of GI function Flashcards

1
Q

what is the enteric nervous system

A

short reflex arcs located within wall of GI tract and can operate independently of rest of body
has sensory and motor cells

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2
Q

what do simple reflex arcs consist of

A

single sensory cell and a single motor nerve cell.

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3
Q

what do complex reflex arcs consist of

A

single reflex arcs connected by interneurons

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4
Q

what do short reflex arcs enable

A

enable GI tract to have extensive control of its activities

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5
Q

what is the main transmitter of reflex arcs

A

acetylcholine

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6
Q

what does the parasympathetic system promote

A

digestion

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7
Q

where are pre-ganglionic fibres located (parasympathetic)

A

vagus nerve

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8
Q

where are post ganglionic fibres located (parasympathetic)

A

embedded in the wall of the GI tract and connect to the enteric nervous system

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9
Q

where are pre-ganglionic fibres located in the sympathetic NS

A

run in splanchnic nerves

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10
Q

what is the transmitter of pre-ganglionic fibres in SNS

A

acetylcholine

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11
Q

where are post-ganglionic fibres located in SNS

A

run along arteries to organ of innervation or in hypogastric nerves

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12
Q

what is the transmitter of post-ganglionic in SNS and function

A

noradrenaline to inhibit secretion, motility and decrease blood supply to the GI tract

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13
Q

what do entero-enteric reflexes do

A

co-ordinate activity between different parts of the GI tract

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14
Q

where is the production site of the hormone gastrin

A

caudal stomach

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15
Q

what is the stimulation of hormone Gastrin

A

peptides and amino acids
acetylcholine

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16
Q

what effect does the hormone Gastrin have

A

stimulates HCL, stimulates grown of gastric/intestinal mucosa

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17
Q

production site of secretin

18
Q

what is the stimulation of secretin

19
Q

effect of secretin

A

stimulates pancreatic HCO3-

20
Q

production site of CCK

21
Q

stimulation of CCK

A

fatty acids, monoglycerides, amino acids, peptides

22
Q

effect of CCK

A

stimulates pancreatic enzymes
contracts gall bladder

23
Q

production site of Gastric Inhibitory Peptide (GIP)

A

cranial small intestine

24
Q

stimulation of GIP

A

fat, glucose, amino acids

25
effect of GIP
inhibits HCL stimulates insulin production
26
what are the 3 phases of regulation
cephalic phase - head gastric phase - stomach intestinal phase - intetines
27
what is the cephalic phase co-oridinated by
ANS
28
what is the gastric phase co-ordinated by
ANS, ENS and hormones - gastrin
29
what is the intestinal phase co-ordinated by
ANS, ENS, and hormones - secretin, CCK and GIP
30
what is the regulation of appetite controlled by in the brain
hypothalamus
31
what does the appetite centre do
causes food searching and voracious eating direct effect on animals behaviour
32
what does the satiety centre do
causes refusal of food inhibits appetite centre
33
what are the 3 theories of mechanism of action
glucostat cck lipostat
34
what is motility
co-ordinated contraction of smooth muscle in the GI tract
35
what are the 4 types of contraction
segmental peristalsis anti-peristalsis mass movement
36
what is segmental contraction
mixes lumen contents mechanical breakdown
37
what is peristalsis
move intestinal contents in a gradual aboral direction
38
what is anti-peristalsis
moves intestinal contents in an oral direction eg rumination/vomiting
39
what is mass movement
empties entire sections of GI tract eg evacuate colon contents into rectum prior to defaecation
40
what happens when pacemaker cells reach threshold potential
action potential to cause smooth muscle contraction
41
what determines strength of contraction
frequency of action potentials
42
what are action potentials due to
opening of calcium channels