liver Flashcards
where is the liver located
dome of the diaphragm within the abdominal cavity
what do liver lobes allow
movement of organ due to diaphragm
what is the liver surrounded by
capsule of connective tissue
what are hepatocytes
chief functional cells of liver
what do hepatocytes do
absorb molecules from space of disse
what is bile canalicus
dilated intracellular space between cells
what does the biliary system do
conveys bile from liver to duodenal system
what is the hierarchy of the biliary system
hepatocytes
canaliculi
ductules
ducts
hepatic bile ducts + gallbladder - cystic duct
common bile duct
blood supply of the liver
hepatic portal vein
hepatic artery
sinusoids
central veins
hepatic veins
caudal vena cava
shape of hepatic lobules and what are they made of
hexagonal
plates of hepatocytes
what is the functional unit of the liver
hepatic acinus
what are sinusoids
vascular channels
functions of the liver
detoxification of body wastes, xenobiotics and drugs
synthesis of cholesterol and bile ducts
synthesis of plasma proteins
breakdown of RBC
carbohydrate, lipid and amino acids metabolism
removal of bacteria
production of clotting factors
storage of glycogen, iron, copper and vitamins
purpose of detoxification and clearance
removes harmful substances from blood
how are RBCs removed from blood
by macrophages in spleen and liver
what part do bile pigments play in digestion
no part
waste route for haem
functions of bile
promotes hydrolysis by lipases
facilitates intestinal absorption of lipids
exit route for waste products and drugs
what is bile composed of
water
electrolytes
biliary proteins
bile pigments
cholesterol
phospholipids
bile acids
where is bile stored
gall bladder
what are secondary bile acids
primary acids moved into ileum and deconjugated and converted into secondary bile acids
process of bile acid secretion
transported into bile canaliculus
bile canaliculi isolated from hepatocyte cell membrane by tight junctions to prevent leakage
bile canaliculi feed into large canals
bile emptied into duodenum at major duodenal papilla
bile salts not soluble so remain in SI lumen until actively reabsorbed in ileum
what is the recycling of bile acids called
enterohepatic circulation
regulation of bile secretion
parasympathetic system
CCK and Secretin
amount of bile salts returning to liver via enterohepatic circulation
why is CCK released in bile secretion
presence of fat in duodenum
