Regulation of cellular respiration

Question 1

major allosteric control points in
glycolysis:

Answer 1

Hexokinase at step 1
Phosphofructokinase-1 at step 3
Pyruvate kinase at step 10

Question 2

glucagon in liver reduces [Fructose 2,6 bisphosphate] => inhibits glycolysis, stimulates ???

Answer 2

gluconeogenesis

Question 3

glucagon inhibits ??? which prevents phosphoenolpyruvate from being
converted to acetyl-CoA

Answer 3

pyruvate kinase

Question 4

How many hexokinase isozymes are there?

Answer 4

4

Question 5

Where are hexokinase I, II, II found?

Answer 5

muscle cells

Question 6

Hexokinase II is the predominant isozyme as it has a high affinity for ???

Answer 6

glucose

Question 7

Isozymes I, II and III are allosterically inhibited by their product:
???

Answer 7

glucose 6-phosphate

Question 8

Hexokinase IV (aka glucokinase) is only expressed in the ???

Answer 8

Liver

Question 9

TRUE or FALSE: Hexokinase IV is allosterically inhibited by G6P

Answer 9

FALSE, insulin controls it, not G6P

Question 10

Hexokinase IV is regulated by Insulin and ???

Answer 10

sequestration

Question 11

High [F2,6BP] activates ??? whislt Low inhibits

Answer 11

glycolysis

Question 12

TRUE or FALSE: PFK-1 is almost inactive in the absence of F26BP

Answer 12

TRUE

Question 13

At which steps is the TCA cycle regulated highly thermodynamically favourable and irreversible steps?

Answer 13

PDH complex, citrate synthase, Isocitrate Dehydrogenase and α-Ketoglutarate Dehydrogenase

Question 14

hypoxia