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Biol214 > Oxidative Phosphorylation > Flashcards

Oxidative Phosphorylation Flashcards

1
Q

Oxidative phosphorylation occurs in the ???

A

matrix

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2
Q

the electron transport chain is embedded in the ??? of the mitochondria

A

the INNER mitochondrial membrane

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3
Q

Complex I is called ???

A

NADH dehydrogenase

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4
Q

Complex II is called ???

A

Succinate dehydrogenase

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4
Q

Complex III is called ???

A

Ubiquinone:cytochrome c
oxidoreductase

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5
Q

Complex IV is called ???

A

cytochrome oxidase

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6
Q

Complex V is the ATP synthase and is the ??? component of oxidative phosphorylation

A

phosphorylation

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7
Q

Which complex doesn’t do H ion pumping?

A

Complex II

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8
Q

Which complex(es)
exhibit Fe-S centers?

A

Complexes I, II, III

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9
Q

How many electrons do the complex(es)
exhibiting Fe-S centres carry?

A

1 electron (Ubiquinone by itself carries 2 e)

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10
Q

Name the amino
acid the Fe-S exhibiting complexes are bound to

A

Cysteine

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11
Q

TRUE or False: coenzyme Q (Ubiquinone) carries 2 electrons

A

True

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12
Q

What is the final e– acceptor of the ETC?

A

oxygen

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13
Q

Coenzyme Q (Ubiquinone) is ??? and can OR can’t freely diffuse within the
lipid bilayer of the inner
mitochondrial membrane?

A

lipid soluble, CAN freely diffuse

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14
Q

Coenzyme Q (Ubiquinone) Can OR Can’t shuttle reducing equivalents between other less mobile components?

A

It can

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15
Q

Cytochrome C is a soluble or insoluble heme-containing protein in the intermembrane space

A

soluble

16
Q

Cytochrome C is a ??? carrier

A

mobile electron

17
Q

Complex I to Complex IV reaction for NADH:
1 NADH, ???H (M) + ½O2 —> NAD+ + ???H+ (IMS) + H2

A

11 H+ ions to 10H+ ions

18
Q

Complex II to Complex IV reaction for FADH:
FADH2 + ???H+ (M) + ½O2 —> FAD + ???H+ (IMS) + H2O

A

6H+ ions to 6H+ ions

19
Q

What is the purpose of dehydrogenations of NADH, FMNH2, FADH2 and the reactions oxidising Coenzyme Q and Cytochrome C?

A

They pump protons (H+) into the
intermembrane space which is used to set up an electrochemical gradient

20
Q

why is an electrochemical gradient set up?

A

to drive ATP synthesis

21
Q

the FO component of ATP synthase is the ??? spanning domain

A

membrane-spanning domain

22
Q

The FO component of ATP synthase transports H+ from IMS to ???,
dissipating the proton gradient.

A

matrix

23
Q

the O in FO comes from ??? sensitivity.

A

oligomycin

24
Q

Energy transferred from ??? to F1
to catalyze phosphorylation of
ADP

A

FO to F1

25
Q

F1 component of ATP synthase is the ATP ??? domain and a soluble complex in the matrix

A

ATP synthesizing domain

26
Q

In ATP synthase, A total of ??? H+ are transported per ATP generated by ATPase

A

A total of 3 H+ are transported
per ATP

27
Q

TRUE or FALSE: An extra H+ is used by ATPase to transport phosphate (H2PO4- is required for ATP synthesis)

A

TRUE

28
Q

Binding-Change model of ATPase: proton-motive force causes rotation of the ??? —the γ subunit

A

central shaft

29
Q

ATPase: the γ subunit contacts each αβ subunit pair in succession.
= ??? which ejects ATP from the β-ATP site. The β-ADP site is converted to the β-ATP conformation, which
promotes condensation of bound
ADP + Pi to form ATP

A

conformational change

30
Q

Oxidative phosphorylation can be discoupled by: ??? (such as digitonin), chemicals such as dinitrophenol, an uncoupling protein

A

disrupting membranes with detergents

31
Q

Non-shivering thermiogenesis: The inner membrane of brown fat mitochondria is very permeable to H+ and UCPs allow H+ leak back across the inner membrane. Heat is produced instead of ???

A

ATP

32
Q

UCP1 reduces the number of ??? that can be made from a given amount of food, raising the body’s
metabolic rate and generating heat.

A

ATPs

33
Q

UCP2 is expressed in brain, fat, muscle, and b-cells of the pancreas. UCP3 is expressed mostly in ???

A

muscle

Biol214 (12 decks)

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