Regulation of Body Weight and Food Intake

Question 1

Anabolic pathways for E homeostasis

Answer 1

Eat more

Inhibit E expenditure

*overeating will put you in + E balance –> accumulation of adipose tissue

Question 2

Catabolic pathways for E homeostasis

Answer 2

Eat less

Stimulate E burned

*overeating will put you in + E balance –> accumulation of adipose tissue

Question 3

Lateral nucleus of hypothalamus

Answer 3

LH = Hunger center

*ablate it in a rodent: - they stop eating

Question 4

Ventromedial Nucleus

Answer 4

VMN = satiety Center
- tells you when full

*ablate it: cant stop eating

Question 5

Leptin

Answer 5

Signal from body to tell your body to keep catabolic and anabolic pathways in balance
- Stimulates catabolic
- Inhibits Anabolic
(you shouldnt be hungry)

Tells your body we gots enough! Enough is enough.
- maybe weight prone people are resistant to leptin

Question 6

Arcuate nucleus

Answer 6

NPY/AgRP
- stimulates neurons in PVN/LHA, NPYR –>
increase food intake
Decrease E expenditure

POMC/CART
- stimulates MCR in PVN/LHA –>
decrease food intake
Increase E expenditure

Question 7

Leptin + insulin stimulate which system? Inhibit which?

Answer 7

Stimulates:
- catabolic
(eat less)

Inhibits:
- anabolic
(eat more)

*you are full/have food, stop eating

Question 8

Ghrelin and PYY and

GLP-1

Answer 8

Hormones
Ghrelin from stomach
- stimulates appetite center to make you hungrier

PYY+GLP-1 from distal ileum

• Satiety hormones
• meal to meal regulation

These hormones are counterbalancing eachother

Question 9

Ghrelin and PYY effects on:

NPY/AgRP and POMC/CART

Answer 9

Ghrelin + (stim) NPY/AgRP

• inhibits POMC/CART
• -> Increase food intake

PYY 
- Inhibits NPY/AgRP
- Stimulates POMC/CART
-->
Decrease food intake

Question 10

Responses to seeing food, then eating food, what happens to their brain?

Answer 10

Obese resistant

• see food, want food
• eat food, then signaling goes down

Obese Prone

• see food, dont want food as much
• eat food, signaling goes way up

*reactions are completely different

Question 11

Homeostatic signals that feed hypothalamus

Answer 11

1. adiposity signals
2. metabolites
3. gut peptides
4. gastric distention