Regulation + Fibrinolysis Flashcards
Protein C
dependent on
activated by
inactivates
liberates
cofactor?
Vit K dependent
activated by thrombin- thrombomodulin complex
INACTIVATES Va VIIIa
LIBERATES tissue plasminogen activator (tPA) from endo cells
protein S cofactor
Protein S
dependent?
60%
other %?
cofactor?
Vit K dep
C4b bound 60%
40% free - active in coag
cofactor for C
Protein Z
dep
cofactor for?
major role?
requires?
vit K dep
cofactor for protein z related protease inhibitor (ZPI)
major role degrade Xa
requires Ca++/Lipids/Slow acting
ZPI
dep
cofactor for?
degrades?
accelerated?
vit K dep
cofactor for Protein Z
degrades Xa and XIa
accelerated 1000 fold w protein Z
Anti-thrombin (AT III)/ AT
forms irreversable xomplex w IIa, IXa, Xa, XIa, XIIa
and plasmin to neutralize tgem
heparin causes conformational changes and increases inhibition effects
Heparin coactor II (HC-II)
IIa neutralization
accel activity in presence of heparin
Tiss factor pathway inhibitor (TFPI)
Inhibits TF/Factor VIIa complex
extrinsic path inhibitor
Plasminogen activators
Endogenous
act protein C to TPA
Urokinase
XIIa/Kalikrein
XIa minor role
Exogenous plasminogen activators
Tpa
streptokinase
urokinase
Functions of plasmin
lyses
most active? destroyed by?
circulating…
lyses both fibrin/fibrinogen
most active in clot, any outside destroyed by anti-plasmins
circulating plasmin in plasma norm to low to achieve fibrinolysis
Primary fibrinolysis
fibrinogenolysis
lysis of fibrinogen
Secondary fibrinolysis
fibrinolysis
lysis of fibrin
Other functions of plasmin
inact..
degrade
Inactivate Va/VIIIa
degrade XIIIa into inactive fragments
Fibrinogenolysis
fragments XYDE - FDP
XY intermediate
D+E end products
FDP can be coag inhibitors ad prevent clot formation
Fibrinolysis
fibrin monomer
