Factor deficiencies and inhibitors

Question 1

Which Acquired Factor deficiency can be caused by Amyloidosis

Answer 1

X

Question 2

Which Fibrinogen Disorder would have an abnormal bleeding time

Answer 2

afibrinogenemia

Question 3

If there is a deficiency of vonWillebrands factor, which other factor will also be affected
and why?

Answer 3

VIII, VWF is a carrier of VIII

Question 4

Why is the bleeding time normal in Hemophilia A

Answer 4

VIII def will not affect plt function which is tested in bleeding time

Question 5

Even though disseminated intravascular coagulation is a thrombotic process, why is
systemic hemorrhage one of the first signs or symptom

Answer 5

many clotting factors are consumed

Question 6

Prekallekrein deficiency is most often associated with what sort of hemostatic disorder

Answer 6

thrombosis - mostly asymptomatic

Question 7

Bill and Joe’s family have a very rare disease which causes them several problems. Their
symptoms include poor would healing, excessive scarring, slow bruise healing, and
cranial hemorrhages. Laboratory testing reveals the following: Bleeding time – normal,
PT – normal, APTT – normal. What is the most likely hemostatic disorder afflicting this
family?

Answer 7

XIII deficiencies

Question 8

Hemophilia B is a deficiency of what factor and be the result of the following screening
tests (BT, PT, APTT)

Answer 8

IX

BT normal
PT normal
APTT prolonged

Question 9

An alpha 2 anti-plasmin deficiency will most likely lead to what sort of hemostatic
disorder and why?

Answer 9

bleeding because plasmin will not be inhibited and will break down pts fibrinogen

Question 10

Tissue plasminogen activator deficiency causes what type of hemostatic disorder and
why?

Answer 10

thrombosis because plasminogen isnt activated to plasmin, decreasing breakdnwon of fibrin clots

Question 11

Which pathological or abnormal inhibitor is most often time and temperature
dependent and why is knowledge important to testin

Answer 11

VIII:C inhibitor, incubate for 30-1hr

Question 12

Which is the rarest congenital factor deficiency

Answer 12

II prothrombin

Question 13

What is a common complication in hemophilia A patients that have received many
doses of Factor VIII concentrate

Answer 13

deveople VIII inhibitor

Question 14

is dysfunctional fibrinogen associated with bleeding or thrombosis

Answer 14

both

Question 15

What disorder is also known as the “royal disease”, and is thought to have originated
from a random mutation in Queen Victoria? What factor is involved with this disorder

Answer 15

hemophilia B
IX

Question 16

For which coagulation factor is lupus inhibitor specific

Answer 16

none - antiphospholipid ab

Question 17

What do Anti-cardiolipin Antibody, Lupus Inhibitor and Anti-Beta 2 glycoprotein I all
have in common?

Answer 17

all antiphospholipid antibodies