Exam Review 1

Question 1

What is not involved in a complex in the cascade?

Answer 1

11a

Question 2

What are the magic 4?

Answer 2

II, VII, IX, X

Question 3

These polymerize and stablize factor XIIIa

Answer 3

Fibrin Monomers

Question 4

Factor VIII needs what for stability? What to be activated?

Answer 4

Needs VWF to be stabilized and IIa to be activated

Question 5

What proteins prevent excess clotting?

Answer 5

Activated protein C and protein S

Question 6

What degrades Fibrin

Answer 6

Plasmin

Question 7

What DOES NOT activate plasminogen directly?

Answer 7

Thrombin

Question 8

What DOES NOT inhibit fibrinolysis

Answer 8

Protein Z

Question 9

PT HCT 63%

Answer 9

sample needs to be redrawn into a Sodium Citrate tube using less anticoag to account for increased HCT

Question 10

Mod thrombocytopenia,
Large PLTS
normal PT/APTT
normal plt aggregometry except for ristocetin

Answer 10

Bernard Soulier syndrome

Question 11

Normal PLT count
WBC RBC PLT morph normal
norm PT APTT
prolonged PFA
no norm aggregation except with ristocetin

Answer 11

Glannzmans thrombothasemia

Question 12

vWF:Rco confirmatory test for vonwillebrands disease

Answer 12

pt plasma and donor pLTS are used to measure ability of pt vwf to agglutinate donor plts

Question 13

Normal plt count/morph/curve
normal primary wave, no secondary wave with ADP/EPI
prolonged PFA

Answer 13

Delta storage pool disease

Question 14

Easy brusing, menorrhagia. PLT count 60,000 - everything else normal. PLT has IgG autoab

Answer 14

ITP

Question 15

most commonly diagnosed in children after viral infection

Answer 15

Acute immune thrombocytopenic purpura

AITP

Question 16

Common drug causing thrombocytopenia and thrombosis

Answer 16

heparin

Question 17

Fever, bouts of confusion, decreased PLTs
moderate anemia
schistocytes
polychromasia and nRBCS

PT APTT normal

BUN/CREAT elevated

Answer 17

TTP

Question 18

4 yr old, undercooked ground beef with kidney issues

Answer 18

HUS

Question 19

What is deficient in TTP

Answer 19

ADAMTS13

Question 20

How does heparin therapy work?

Answer 20

causes conformational changes in AT molecule

Question 21

Pregnant woman, dark urine, schistocytes high bilirubin..etc

Answer 21

HELLP

Question 22

What do not activate the thrombin/thrombomodulin complex

Answer 22

FDPs

Question 23

What doesnt have anything to do with vitamin K?

Answer 23

Aspirin

Question 24

Protein Z and ZPI

Answer 24

degrade X / XI

ZPI - XIa

Question 25

HITTS complex

Answer 25

Anti-PF4/heparin complex activate Fc receptors releasing pro-coag microparticles resulting in thrombosis

Question 26

TAFI

Answer 26

alters the fibrin clot so it is less recognizeable

Question 27

“Clot busters”

Answer 27

convert plasminogen to plasmin

Question 28

When testing for HIT/HITTS

Answer 28

Donor PRP is tested with pt PPP and dilutions of heparin

Question 29

Deficiency of TFPI will result in

Answer 29

Thrombosis

Question 30

APC requires

Answer 30

cofactor protein S

Question 31

Pt may recieve heparin and coumadin for 5 days because

Answer 31

coumadin takes this long to produce its full anticoag effect

Question 32

An unexpectedly small anticoag response in a pt recieving heparin therapy may be caused by a decreased level of

Answer 32

AT

Question 33

What is not a vascular defect?

Answer 33

Hermansky-Pudlak