Exam Review 1 Flashcards
What is not involved in a complex in the cascade?
11a
What are the magic 4?
II, VII, IX, X
These polymerize and stablize factor XIIIa
Fibrin Monomers
Factor VIII needs what for stability? What to be activated?
Needs VWF to be stabilized and IIa to be activated
What proteins prevent excess clotting?
Activated protein C and protein S
What degrades Fibrin
Plasmin
What DOES NOT activate plasminogen directly?
Thrombin
What DOES NOT inhibit fibrinolysis
Protein Z
PT HCT 63%
sample needs to be redrawn into a Sodium Citrate tube using less anticoag to account for increased HCT
Mod thrombocytopenia,
Large PLTS
normal PT/APTT
normal plt aggregometry except for ristocetin
Bernard Soulier syndrome
Normal PLT count
WBC RBC PLT morph normal
norm PT APTT
prolonged PFA
no norm aggregation except with ristocetin
Glannzmans thrombothasemia
vWF:Rco confirmatory test for vonwillebrands disease
pt plasma and donor pLTS are used to measure ability of pt vwf to agglutinate donor plts
Normal plt count/morph/curve
normal primary wave, no secondary wave with ADP/EPI
prolonged PFA
Delta storage pool disease
Easy brusing, menorrhagia. PLT count 60,000 - everything else normal. PLT has IgG autoab
ITP
most commonly diagnosed in children after viral infection
Acute immune thrombocytopenic purpura
AITP
Common drug causing thrombocytopenia and thrombosis
heparin
Fever, bouts of confusion, decreased PLTs
moderate anemia
schistocytes
polychromasia and nRBCS
PT APTT normal
BUN/CREAT elevated
TTP
4 yr old, undercooked ground beef with kidney issues
HUS
What is deficient in TTP
ADAMTS13
How does heparin therapy work?
causes conformational changes in AT molecule
Pregnant woman, dark urine, schistocytes high bilirubin..etc
HELLP
What do not activate the thrombin/thrombomodulin complex
FDPs
What doesnt have anything to do with vitamin K?
Aspirin
Protein Z and ZPI
degrade X / XI
ZPI - XIa
HITTS complex
Anti-PF4/heparin complex activate Fc receptors releasing pro-coag microparticles resulting in thrombosis
TAFI
alters the fibrin clot so it is less recognizeable
“Clot busters”
convert plasminogen to plasmin
When testing for HIT/HITTS
Donor PRP is tested with pt PPP and dilutions of heparin
Deficiency of TFPI will result in
Thrombosis
APC requires
cofactor protein S
Pt may recieve heparin and coumadin for 5 days because
coumadin takes this long to produce its full anticoag effect
An unexpectedly small anticoag response in a pt recieving heparin therapy may be caused by a decreased level of
AT
What is not a vascular defect?
Hermansky-Pudlak
