Regional Immunity Flashcards
1
Q
GALT Dependent IgA Class Switch
A
DCs migrate to GALT, show to Th2, stimulate CS via IL-5 and TGF-Beta
2
Q
GALT Independent IgA Class Switch
A
DCs present Ag to Bs directly locally in the gut, using retinoic acid to mediate the CS
3
Q
M Cell
A
In GALT, vacuum up Ags and are closely associated with DCs, Bs, and Ts, so they can give Ag to DC and immediate immune response.
4
Q
Gut Endothelial Cell Stimulatory Action
A
Have TLRs that bind PAMPs, then release chemokines to stimulate DCs
5
Q
Non-Immune Defense
A
Commensal bacteria outcompeting pathogens
6
Q
Intracellular Infection Response of Endothelial Cells
A
Express stress prots MIC1/2 on surface
gammadelta Ts bind this via a R shared w/ NKs and induce apoptosis
