Antibody Mediated Immunity

Question 1

Type I Hypersensitivity

Answer 1

IgEs towards soluble antigens activate mast cells

Question 2

Type II Hypersensitivity

Answer 2

IgGs towards cell surface/matrix associated Ags can cause NK/phagocytic/complement response or inappropriate antibody response, like penicillin allergy

Question 3

Type III Hypersenstivity

Answer 3

IgG towards soluble Ag activates complement and phagocytosis and shit - SLE and serum sickness

Question 4

FcgammaRs (3)

Answer 4

Recognize IgGs
On phagocytic cells and NK cells
Low affinity, so need a lot (like ICs)

Question 5

2 Ways for Phagocytes to Recognize Ag/Ab Complexes

Answer 5

FcgammaR and IgG

CR1 and C3b

Question 6

IgA Production/Transport/Function

Answer 6

Local plasmas produce, dimerizes w/ J chain connection
Poly-Ig R binds, endocytoses into endothelial cells, and protects from proteolysis as it moves it through to lumenal side
“Secretory piece” remains bound and attaches IgA to mucous to create wall that will neutralize incoming paths

Question 7

Brambell Receptor

Answer 7

FcRB which transports IgG from EC space through epithelium and into capillary/tissues or across placental barrier

Question 8

Fcepsilon Rs

Answer 8

On mast cells/basophils, but VERY high affinity for IgE
So these cells “pre-arm” themselves with a bunch of different IgEs
Still require cross linking for activation

Question 9

3 Locations/Actions of Mast Cells

Answer 9

GI - expulsion, peristalsis
Respiratory - expulsion
Blood vessels - increase flow/permeability for inflammation

Question 10

Mast Cells Granule 2 Contents and Effects

Answer 10

Histamine for permeability, parasite toxicity, and smooth muscle contraction, and TNFalpha for inflammation

Question 11

Mast Cell Synthesized/Secreted 4 Contents & effects

Answer 11

Cytokines like TNFalpha and IL-4 - stimulate Th2 activity for IgE class switch
Chemokines
Lipid mediator like leukotrines to cause the permeability/mucous secretion/smooth muscle contraction again

Question 12

Mast Cell Amplification of IgE

Answer 12

Activated mast cells produce CD40L and IL-4 which both interact with B cells to activate and IL-4 preferentially inducing IgE (and IgG)

Question 13

Eosinophils

Answer 13

Have granular (major basic proteins) and synthesized contents which stimulate mast cell degranulation and are toxic to parasites, but you as well so they need to be controlled.