NK Cells/Lymphocytes as Innate Immunity Flashcards
1
Q
2 Very Important Processes NK Cells Involved In
A
Tumor cell killing - hematopoeitic and epithelial cell tumors
Transplant rejection
2
Q
Cell Surface Marker of NK Cells
A
CD56
3
Q
3 NK Activating Molecules from Macs
A
IL-12 - activation (produce more granules)
TNFalpha
IL-15 - antiapoptosis
4
Q
3 Things in NK Cells w/ ITAM residues
A
KIRs signal ITAMs on zeta chains
FcRgamma Rs have ITAMs
DAP12 has ITAMs and goes through PI3K pathway
5
Q
NKG2D
A
Activating R present on all NKs that binds MIC A/B
6
Q
Rituximab Action
A
Abs w/ Fc region that binds FcR on NK cells to target them towards CD20 (on tumor cells)
