Regal IHO Week 6

Question 1

irreversible ADP receptor antagonists that prevent activation of ADP receptor, oral drugs with duration of days, used in stenting for pt. that can’t take aspirin, AE: bleeding and thrombocytopenic purpura

Answer 1

Clopidogrel, Prasugre, Ticopidine

Question 2

What 2 ADP receptor antagonists have less AE

Answer 2

Copidogrel and Prasugrel

Question 3

What needs activation via CYP2C19? (omeprazole impairs this isoform)

Answer 3

Clopidogrel

Question 4

ADP Receptor Antagonists (Clopidogrel, Prasugrel and Ticopidine) reversible or no?

Answer 4

No, not for life of the platelet

Question 5

prevent binding of adhesive glycoproteins such as fibrinogen and vWF to activated platelets; inhibits final common pathway for platelet aggregation, given IV, AE: bleeding and thrombocytopenia

Answer 5

GPIIb/IIIa Receptor Inhibitors (Abciximab, Eptifibatide and Tirofiban)

Question 6

humanized MAB against GPIIb/IIIa

Answer 6

Abxicimab

Question 7

fibrinogen analogue

Answer 7

Eptifibatide

Question 8

non-peptide competitive inhibitor

Answer 8

Tirofiban

Question 9

given IV: with aspirin and heparin during angioplasty and for acute coronary syndromes; AE bleeding, thrombocytopenia

Answer 9

GPIIb/IIIa Receptor Inhibitors