Millikan IHO Week 3 Flashcards

(26 cards)

1
Q

anti-tubulin, small, epithelial malignancies, especially breast and ovarian

A

Paclitaxel

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2
Q

topisomerase inhibitor, small, breast cancer, lymphoma

A

Doxorubicin

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3
Q

topoisomerase inhibitor, small, germ cell tumors, lymphoma

A

Etoposide

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4
Q

proteosome inhibitor, small, multiple myeloma, mantle cell lymphoma, Waldenstroms (a type of non-hodgkin lymphoma)

A

Bortexomib

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5
Q

active metabolite (SN-38) can be liberated by ubiquitous hydrolytic enzymes in/outside of cells; in the liver oxidized by several different P-450 members and conjugated to sugars to bile to excreted; gut flora can convert back to SN-38

A

Irinotecan (in the family of Camptothecins)

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6
Q

4 Pharmacologic Points for Irinotecan

A
  1. inhibits the re-ligation step of Topo1 activity 2. prodrug of SN-38 and relies on intact lactone 3. effort to make analogs with improved TI 4. now formulated in 2 ways
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7
Q

3 Clinical Points for Irinotecan

A
  1. GI cancers including the pancreas 2. DLT is diarrhea 3. neutropenia is not cumulative and the drug can be given for extended time (>1yr)
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8
Q

What causes intercalation into DNA (pi stacking)

A

Doxorubicin

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9
Q

What causes most of the toxicity in use of Doxorubicin

A

generation of ROS and blocking of Topo 2

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10
Q

What do you give to help prevent Doxorubicin toxicity

A

Iron Chelators

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11
Q

4 Clinical Points for Doxorubicin

A
  1. broad spectrum anti-cancer activity 2. DLTs are stomatitis and myelosuppression 3. cardiac damage 4. nasty vesicant
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12
Q

broad spectrum anti-cancer drug essential for small cell carcinoma of lung and germ cell tumors and (aggressive lymphomas)

A

Etoposide

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13
Q

Causes acute leukemia at 1-2 per thousand at 2-3 yr latency, rapidly fatal, DLT is myelosuppression

A

Etoposide

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14
Q

Work by inhibiting tubulin polymerization and thereby causing mitotic arrest

A

Vinca alkaloids

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15
Q

Dose limiting toxicity of Vinca Alkaloids

A

neuropathy

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16
Q

What is not very myelosuppressive and is added to many regimens

17
Q

What is extremely constipating

18
Q

What works by binding to inner surface of microtubules where GDP binds the beta-subunit and stabilizes the structure, preventing depolymerization

19
Q

Dose limiting toxicity of the Taxanes

20
Q

Most common chemotherapy for solid tumors combination?

A

carboplatin and paclitaxel

21
Q

What binds to the positive end of microtubule preventing elongation (doesn’t seem to work)?

22
Q

Drug that causes myelosuppression and is dose-limiting and neuropathy

23
Q

If can’t feel feet think what category of cancer med?

A

Anti-microtubule agent (Paclitaxel)

24
Q

What blocks the 26S proteasome proteolytic activity (a threonine protease) given IV or subq

25
Dose limiting effects of Bortezomib?
fatigue, neuropathy and myelosuppression
26
Extremely important in myeloma and other B-cell malignancies
Bortezomib