Diebel IHO Week 2 Flashcards
TH1 CD4+ Tcells Polarized by
IL-12, IL-18 and IFNgamma
Effector Cytokines of Th1 CD4+
IFNgamma and TNF
HLA-B27 are 90x more likely to develop what
ankylosing spondylitis (also linked to psoriasis, IBD, reiter’s syndrome)
Narcolepsy risk with which HLA
HLA-DR
What activates early B cell genes
E2A and EBF
What ensures development to B cell lineages via restricting transcription of lineage inappropriate genes and activating expression of B lineage signaling molecules
Pax5
what is needed for survival and proliferation of pro-B cells
Sox4 and LEF1
What terminates pre-BCR signaling by IRF4 and promotes differentiation to small pre-B cells
IRF4 and IRF8
what is required for germinal B-cell differentiation and generation of memory B cells
Bcl-6
What suppresses Bcl-6 for long lived plasma cells
Blimp-1
Agammaglobulinemia in 85% of cases
BTK (Bruton’s tyrosin kinase) without it no signal transduction of preBCR and BCR
What has reduced serum Ig, memory B cells. class switch recombination and B-cell activation; mutations in CD40 ligan on Tcells/BCR CD19, activated Tcell costimulatory molecule ICOS, and TACI
Common Variable Immunodeficiency
2 Fates if immature B cells express mIgM that recognize self antigen in bone marrow
- undergo apoptosis 2. undergo editing of light chain genes to produce a different light chain that (when combined with the heavy chain) does not recognize self antigen
Which T-independent antigen is primarily for bacterial cell wall components?
TI-1
Which T-independent antigen is primarily for large polysaccharide molecules with repeating antigenic determinants (Ficoll, dextran, polymeric bacterial flagellin, and poliomyelitis virus)
TI-2
