Red cell disorders Flashcards
1
Q
What is the goal of transfusion in thalassemia major? What should the transfusion targets be?
A
Prevent growth impairment and reduce damaging effect of EMH.
Target hemoglobin of 9+, transfusing every 2-4 weeks.,
2
Q
What percentage of sickle cell patients alloimmunize?
A
20%
3
Q
What is a unique laboratory finding in sickle cell hyperhemolysis?
A
Reticulocytes fall, not rise.
4
Q
What are some indications for exchange transfusion in sickle cell anemia?
A
Severe acute chest syndrome (refractory low oxygen sats), stroke, hepatic sequestration, high TCDs, cholestasis, and multiorgan dysfunction.
5
Q
What are some indications NOT to exchange in sickle cell anemia?
A
Uncomplicated VOC, priapism, asymptomatic anemia, acute kidney injury.
