Clinical trials

Question 1

TRICC

Answer 1

Restrictive (<7g/dL) vs liberal (<10g/dL) RBC transfusion thresholds have no difference in 30d mortality.

Restrictive thresholds have better mortality in young and less-acute patients.

Question 2

FOCUS

Answer 2

Restrictive (<8g/dL) vs liberal (<10g/dL) RBC transfusion thresholds have no mortality difference in hip fracture patients.

Question 3

TITRe2

Answer 3

Restrictive (<7.5g/dL) vs liberal (<9g/dL) RBC transfusion thresholds is not superior with regards to mortality (controversial due to confounding bias)

Question 4

STOP, STOP2

Answer 4

STOP: Chronic transfusion reduces the risk of stroke in sickle-cell patients with abnormal transcranial doppler ultrasounds.

STOP2: Stopping prophylactic exchange restores that risk.

Question 5

TWITCH

Answer 5

Hydrea is non-inferior to chronic transfusion in sickle cell patients with abnormal transcranial doppler ultrasounds RE: stroke risk reduction.

Question 6

ARIPI

Answer 6

Fresh RBC units are non-superior to random units in neonates

Question 7

ABLE

Answer 7

Fresh RBC units are non-superior to random units in ICU patients

Question 8

RECESS

Answer 8

Fresh RBC units are non-superior to random units in cardiac surgery patients

Question 9

TOTAL

Answer 9

Fresh RBC units are non-superior to random units in children with severe anemia.

Question 10

INFORM

Answer 10

Fresh RBC units are non-superior to random units in adult inpatients.

Question 11

WENDT

Answer 11

Not transfusing platelets prophylactically in heme/onc patients results in more bleeding.

Question 12

TOPPS

Answer 12

Prophylactic platelets in Heme/onc patients improves survival slightly; this effect is greater in patients receiving chemo or HSCT for AML than autologous HSCT patients.

Question 13

PLADO

Answer 13

Prophylaxis with low-dose (1/2) platelets is non-inferior RE: survival to medium or high-dose (2x) platelets, but at the cost of more transfusions.

Question 14

TRAP

Answer 14

Using apheresis, leukoreduced, or irradiated platelets reduces the rate of alloimmunization as compared to regular acrodose/6pack platelets.

Question 15

PROMMTT

Answer 15

Adult traumas (that live more than 30min) survive better on 1:1 RBC:plasma than >1:1

Question 16

PROPRR

Answer 16

Adult traumas do as well on 1:1 RBC:Plasma as 2:1.

Question 17

FIB-PPH

Answer 17

Fibrinogen concentrate is no better than placebo in pregnant women?

Question 18

RING

Answer 18

In neutropenic patients, granulocytes don’t improve

Question 19

CRIT

Answer 19

In critically ill patients, more transfusion is associated with worse outcomes. Probably this is a confounder.

Question 20

SOAP

Answer 20

Leukoreduction reduces some of the mortality associated with multiple transfusions.

Question 21

TRISS

Answer 21

Critically ill (septic) patients had equal survival with 7g/dL threshold as 9g/dL.

Question 22

CRASH-2

Answer 22

Tranexamic acid improves survival in traumas associated with major hemorrhage.

Question 23

PATCH

Answer 23

Platelet transfusion WORSENS outcomes in intracranial hemorrhage following antiplatelet drugs