Red Cell Abnormalies Flashcards
Anisocytosis is detected by
Making blood smear or by checking patients MCV/RDW
RBC that varies in size
Anisocytosis
Diameter of Macrocytosis
> 8 um
Majority of RBCs are larger than normal.
Macrocytosis
Associated with impaired DNA synthesis.
Macrocytosis
Broadfish tapeworm or Diphyllobothrium latum infection
Macrocytosis
Glossitis- inflamed tongue
Macrocytosis
Diameter of microcytosis
<7 um
With wide central pallor
Majority RBC are smaller than normal
Microcytosis
Usually associated with detective hgb formation
Microcytosis
Usually RBC are hypochromic but can be normochromic
Microcytosis
Iron def. anemia and hookworm infection
Microcytosis
Spoon shaped nail
Koilocychia
Microcytosis can be seen in
Thalassemia Anemia of chronic dse Iron deficiency anemia Lead poisoning Sideroblastic anemia
Microcytiv rbc’s with wide central pallor
Ghost cells
HgB distribution is unequal
Anisochromic cells
Central pallor is >1/3 of rbc diameter
Rbc is falsely dec hgb content
Usually microcytic
Hypochromic cells
RBCs falsely inc hgb content
Hyperchromic crlls
Larger than normal with bluish tinge
Caused by residual rna
Causes: dec. rbc survival, hemorrhage or erthyroid hyperplastic marrow
Polychromatophilic Erythrocyte
Residual RNA is stained with what?
Supervital stain not with romanosky stain
Rbc that varies in shape
Poikilocyte
Normal shape of poikilocyte
Biconcave disk; donut shaped without a hole in the middle
Inc rbc flexibility in poikilocyte
Concavitt/depression
Spherical in shape
Lacks cp
MCHC is high
Spherocytes
Spherocytes is seen in
Hemolytic anemia and hereditary spherocytosis
Mouth cell
Elongated rbc with slit like cp
Stomatocytes
Stomatocytes is seen in
Rh null syndrome
Alcholism
Severe liver dse
Hereditary stomatocytosis
Thorn/spurr cells
Rbcs with irregular spiculated surfacen
Acanthocytes
Crenated rbc
With regular spiculated surface
Spicules are rounded at tip
Echinocytes
Echinocytes are seen in
Artificial drying of smear
Bile acids abnormalities
Barbiturates
Salicylates
Regulary spiculated surface with more pointed top
Burr cells
Burr cells is seen in
Pyruvate kinase def
Uremia
Cancer of stomach
Acute blood loss
Other name for ovalocytes
Elliptocytes or cigar cells
Oval shaped rbc
Found in normal persons
Ovalocytes
Ovalocytes can be seen in
Patient with congenital anemia
Other name for dacryocytes
Tear drop cell or tennis racket cell
Pear shaped rbc
Dacryocyte
Dacryocytes is seen in
Myelofibrosis
Myeloid metaplasia
Fragmented rbc
Schistocytes
Schistocyte is seen in
Microangiopathic hemolytic anemia
Uremia
Severe burns
Disseminated intravascular coagulation
Other name for sickle cells
Drepanocytes
Sicke cell or crescent shaped rbc
Sickle cell
Sickle cells is caused by polymerization of an abnormal hgb called hgb s
polymerization of an abnormal hgb called hgb s
Sickle cell is found in
Sickle cell anemia
Other name for target cells
Lepatocyte, Platycyte, codocyte, mexican hat cell
Target cells is seen in
Liver dse and hemoglobinopathies
Thalassemia
Irreg basophilic granules
Stain with deep blue with wright’s stain
Basophilic Stippling
Coarse stippling is seen in
Lead poisoning and other dse with impaired hgb synthesis
Intraerythrocyte collections of ions
Stained with perfs prussian blue
Sideroblastic anemia
Round remnants of nuclear chromatin
Dna composition
Howell-Jolly bodies
Single HJ bodies seen in
Megaloblastic anemia
Hemolytic anemia
Multiple HJ seen in
Megaloblastic anemia
Abnormal erythropoiesis
Remnants of mitotic spindle, probably microtubules.
Ring shaped, figure of eight, loop shaped structures
Evidence of abnormal erythropoiesis
Cabot rings
Cabot rings stained with
Red/Reddish purple with wright’s stain
Malarial stippling for P.vivax
Schuffner’s granules
Malarial stippling for P.falcifarum
Maurer’s dot
Malarial stippling fo P.ovale
Schuffner’s granules
Malarial stippling for P. Malariae
Ziemann’s dot
Aggregation of denatured Hgb
Heinz bodies
Heinz bodies is seen in
G6PD deficiency and hereditary hemolytic anemia following use of oxidizing drugs
Heinz bodies in irreg refractile granules seen in
Periphery of the cell
Normal inclusion of heinz bodies
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