Recreational Drugs

Question 1

How may drug misuse damage health?

Answer 1

Lecture 8, slide 3

Question 2

What are some features of recreational drug use? When does drug addiction become problematic?

Answer 2

Lecture 8, slide 4

Question 3

Give examples of recreational drugs and their corresponding dependence liabilities.

Answer 3

Lecture 8, slide 6

Question 4

What is the key determinant of dependence liability? What is a common feature of it and how can it be measured?

Answer 4

Lecture 8, slide 7

Question 5

Define:
-tolerance
-dependence
-withdrawal
What is addiction sustained by?

Answer 5

Lecture 8, slide 8

Question 6

Give some examples of opiate analgesics, their molecular effects and behavioural effects.

Answer 6

Lecture 8, slide 9

Question 7

Give a molecular model of opiate tolerance, dependence and withdrawal.

Answer 7

Lecture 8, slide 10

Question 8

What are the behavioural effects of opioid-induced withdrawal syndrome? How can this syndrome be precipitated and relieved in opiate dependent individuals?

Answer 8

Lecture 8, slide 11

• high anxiety
• nausea

Question 9

Discuss what the rewarding effects of opiate analgesics involve?

Answer 9

Lecture 8, slide 12

Question 10

Give examples of psychostimulants, their behavioural effects and therapeutic uses. How do they work?

Answer 10

Lecture 8, slide 13

Question 11

What are the effects of cocaine and amphetamine? What do these effects dependent on?

Answer 11

Lecture 8, slide 14

Question 12

Give examples of methylxanthines and their behavioural effects. How do they work?

Answer 12

Lecture 8, slide 15-16

Question 13

What pathway does dependence liability involve?

Answer 13

Lecture 8, slide 17

Question 14

What may OFC and cingulate gyrus deficits be linked to in terms of cocaine addiction

Answer 14

Lecture 8, slide 18

Question 15

Give evidence that dopamine is not required for the rewards effects of morphine

Answer 15

Lecture 8, slide 19

Question 16

What are psychotomimetics?

Answer 16

A drug with psychotomimetic (also known as psychotogenic) actions mimics the symptoms of psychosis, including delusions and/or delirium, as opposed to just hallucinations

Question 17

Give examples of psychotomimetics, their molecular and behavioural effects and therapeutic uses. How do they work?

Answer 17

Lecture 8, slide 20, 24, 25, 27

Question 18

Suggest a potential mechanism of antidepressant action for psychedelic drugs.

Answer 18

Lecture 8, slide 23

Question 19

Is there a correlation between cannabis and schizophrenia?

Answer 19

Lecture 8, slide 26

Question 20

How does alcohol produce its depressant effects? What can frequent use of ethanol induce and how? How is alcohol metabolised?

Answer 20

Lecture 8, slide 29

Question 21

What are benzodiazepines and what is the issue with them?

Answer 21

Lecture 8, slide 30

Question 22

Give examples of pharmacological approaches to treating different aspects of recreational drug dependence.

Answer 22

Lecture 8, slide 31