Introduction to Neuropharmacology

Question 1

Why is the blood brain barrier a challenge for drug development?

Answer 1

Lecture 1, slide 6

Question 2

What is the process if synaptic neurotransmission?

Answer 2

Lecture 1, slide 7

Question 3

Give some examples of neurotransmitters.

Answer 3

Lecture 1, slide 8

Question 4

What is an optimal agonist?

Answer 4

Lecture 1, slide 9

Question 5

Define:

• full agonist
• partial agonist
• inverse agonist

Answer 5

Lecture 1, slide 10

Question 6

Define:

• competitive antagonists
• non-competitive antagonists
• uncompetitive

Answer 6

Lecture 1, slide 11

Question 7

What are the different aspects of drug action?

Answer 7

Lecture 1, slide 12

Question 8

How do we measure the effects of a drug?

Answer 8

Lecture 1, slide 13-14

Question 9

What different types of interactions can drugs have?

Answer 9

Lecture 1, slide 15-16

Question 10

How may the response to a drug change over time? What implications does this have for investigating therapeutic benefit?

Answer 10

Lecture 1, slide 17

Question 11

Give lidocaine as examples of drugs that target ion channels.

Answer 11

Lecture 1, slide 19

Question 12

Give examples of drugs that target neurotransmitter receptors. How is specific targeting by drugs enabled?

Answer 12

Lecture 1, slide 20-21

Question 13

How may neurotransmitter release be targeted by dugs? Give examples.

Answer 13

Lecture 1, slide 22

Question 14

Give examples of drugs that target neurotransmitter transporters.

Answer 14

Lecture 1, slide 23

Question 15

What is the clinical categorization of drugs that affect the brain?

Answer 15

Lecture 1, slide 24

Question 16

What is the general process of clinical trials?

Answer 16

Lecture 1, slide 25