Glutamate

Question 1

How are glutamate receptors localised in the CNS? How can this be visualised?

Answer 1

Lecture 2, slide 3

Question 2

What is glutamate and its structure? How is it transported and why must its levels remain low?

Answer 2

Lecture 2, slide 4

Question 3

How is glutamate synthesised?

Answer 3

Lecture 2, slide 5-6

Question 4

Describe a glutamatergic synapse

Answer 4

Lecture 2, slide 7-8

Question 5

What are the different types of glutamate receptor?

Answer 5

Lecture 2, slide 9-10

Question 6

Discuss the structure and function of AMPA receptors? How is Ca2+ permeability determined?

Answer 6

Lecture 2, slide 11-12

Question 7

Describe the structure of NMDA receptors.

Answer 7

Lecture 2, slide 13

Question 8

What effect does Mg2+ have on NMDA receptors?

Answer 8

Lecture 2, slide 14-15

Question 9

Why can’t size explain the Mg2+ block of NMDA receptors? What can explain the Mg2+ block?

Answer 9

Lecture 2, slide 16-17

Question 10

What does it mean when NMDA receptors are referred to as coincidence detectors?

Answer 10

Lecture 2, slide 18

Question 11

What is long-term potentiation? What does it require?

Answer 11

Lecture 2, slide 19

-persistant increase in the synaptic strength

Question 12

Suggest some potential mechanisms for long-term potentiation and LTD.

Answer 12

Lecture 2, slide 20

Question 13

Discuss the different types of glutamate metabotropic receptors.

Answer 13

Lecture 2, slide 21

Question 14

Discuss the role of glutamate transporters

Answer 14

Lecture 2, slide 22

Question 15

Discuss glutamate in the context of disease

Answer 15

Lecture 2, slide 23