Monoamine Neurotransmitters

Question 1

Describe the general organisation of CNS neurons. Suggest reasons why monoamine neurons have a powerful effect even though they are very small in proportion to other types of neurons?

Answer 1

Lecture 4, slide 4

Question 2

Describe the distribution of CNS noradrenaline pathways.

Answer 2

Lecture 4, slide 5

Question 3

Describe the distribution of CNS dopamine pathways.

Answer 3

Lecture 4, slide 6

Question 4

Describe the distribution of CNS 5-HT pathways.

Answer 4

Lecture 4, slide 7

Question 5

Discuss a study that shows that single monoamine neurons have multiple targets.

Answer 5

Lecture 4, slide 8

Question 6

Give a way in which presynaptic monoamine neurons can interact with multiple postsynaptic neurons.

Answer 6

Lecture 4, slide 9

Question 7

What are some physiological properties of monoamine neurons?

Answer 7

Lecture 4, slide 11-14

Question 8

How can noradrenergic synapses be therapeutically targeted (give examples of drug names)? What are the different types of noradrenaline receptors?

Answer 8

Lecture 4, slide 16

Question 9

Give examples of some strategies that can be used to study noradrenergic neurons.

Answer 9

Lecture 4, slide 17-18

Question 10

What are some CNS functions associated with noradrenaline neurons?

Answer 10

Lecture 4, slide 19

Question 11

What are some therapeutic uses of drugs targeting noradrenaline synapses ?

Answer 11

Lecture 4, slide 20

Question 12

How can dopaminergic synapses be therapeutically targetted (give examples of drug names)? What are the different types of dopamine receptors?

Answer 12

Lecture 4, slide 21

Question 13

Give examples of some strategies that can be used to study dopamine neurons.

Answer 13

Lecture 4, slide 22

Question 14

What drugs activate the mesolimbic dopamine pathway and what does this cause?

Answer 14

Lecture 4, slide 23

Question 15

What are some CNS functions associated with dopamine neurons?

Answer 15

Lecture 4, slide 24

Question 16

What are some therapeutic uses of drugs targeting dopamine synapses?

Answer 16

Lecture 4, slide 25

Question 17

How can 5-HT synapses be therapeutically targeted (give examples of drug names)? What are the different types of 5-HT receptors?

Answer 17

Lecture 4, slide 26

Question 18

Are all 5-HT receptor types expressed by a single neuron? What strategy can be used to answer this question?

Answer 18

Lecture 4, slide 27

Question 19

Is 5-HT the only neurotransmitter released from 5-HT neurons? What strategy can be used to answer this question?

Answer 19

Lecture 4, slide 28

Question 20

What other strategies can be used to investigate 5-HT function? What can these specific strategies be used for?

Answer 20

Lecture 4, slide 29-30

Question 21

What are some CNS functions associated with 5-HT neurons?

Answer 21

Lecture 4, slide 31

Question 22

What are some therapeutic uses of drugs targeting 5-HT synapses?

Answer 22

Lecture 4, slide 32

Question 23

How can monamine systems be imaged in living human brains? What can this strategy be used for?

Answer 23

Lecture 4, slide 33