Receptors in Pharmacology Flashcards
1
Q
What is a receptor in pharmacology
A
Anything that a drug can bind to to produce an effect
2
Q
What are drug receptors
A
- ion channels
- enzymes
- transporters
- physiological receptors (hormone receptors)
- substrates, metabolites, proteins
- DNA,RNA, ribosome
- monoclonal antibodies
- no receptors because you can have physicochemical drugs
3
Q
What are dirty drugs
A
A drugs that can bind to many receptors
4
Q
Give two example of dirty drugs
A
Aspirin
Steroid hormone
5
Q
What is the dirtiest drug called
A
Quetriapine
6
Q
How do drugs have effects on drugs
A
- alter membrane potential if its an ion channel
- alter enzyme activity when bound to enzymes
- alter gene activity
- act like hormones
7
Q
How are receptors classified
A
According to the agonist that binds to it
8
Q
What are the main sub classes of receptors
A
- Ligand gated ion channels
- GPCRs
- nuclear receptors
- integral tyrosine kinase receptors
- cytokines receptors : for TNF
9
Q
Where do nuclear receptors work
A
They work in two main ways
- in the cytoplasm
- in the nucleus
10
Q
How do nuclear receptors in the cytoplasm work
A
Nuclear receptors is bound to HSP ( heat shock protein)
- ligand bind to the NR and HSP leaves
- Two nuclear receptors dimerise
- enter the nucleus and bind to the responce element
- transcription occurs to produce mRNA
- mRNA is translated to a protein
- protein gives signal
11
Q
How do nuclear receptors in the nucleus work
A
- Ligand binds to the nuclear receptor which is bound to RXR (heterodimer)
- transcription occurs to produce mRNA
- mRNA is translated to a protein
- protein gives an effect
