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Cells to Systems > Receptor pharmacology > Flashcards

Receptor pharmacology Flashcards

1
Q

What does Tubocurarine do?

A

Nicotinic receptor antagonist, competitively preventing ACh from binding, resulting in muscle relaxation

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2
Q

What does Atropine do?

A

Muscularinic receptor antagonist, competitively preventing ACh from binding

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3
Q

What does Neostigmine do?

A

AChE inhibitor, resulting in sustained ACh activity

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4
Q

What does Tetrodotoxin do?

A

Voltage gated sodium channel blocker, inhibiting action potential generation

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5
Q

What does Suxamethonium do?

A

Nicotinic receptor agonist

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6
Q

How can Suxamethonium be a nicotinic receptor agonist, except be used as a muscle relaxant?

A

Suxamethonium has a longer duration of effect than ACh and is not broken down by AChE, therefore, preventing muscle cell repolarization

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7
Q

What are the main neurotransmitters and receptors of the sympathetic nervous system?

A

Adrenaline and NA binding to alpha and beta receptors

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8
Q

What are the pre-ganglionic receptors present in the parasympathetic and sympathetic nervous system?

A

Nicotinic

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9
Q

What are the post-ganglionic receptors present in the sympathetic nervous system?

A

Alpha and beta receptors

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10
Q

What does activating alpha-1 receptors do?

A
  1. Vasoconstriction of vascular smooth muscle
  2. Pupil dilation
  3. Urine retention (sphincter contraction)
  4. Glycogenolysis
  5. Inhibit renin release
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11
Q

What does activating alpha-2 receptors do?

A
  1. Decrease in intracellular cAMP (inhibits further NA release)
  2. Decrease insulin secretion
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12
Q

What does activating beta-1 receptors do?

A
  1. Increased HR

2. Increase renin (Increased BP)

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13
Q

What does activating beta-2 receptors do?

A
  1. Bronchodilation
  2. Vasodilation
  3. Decreased gastric motility
  4. Increased insulin secretion
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14
Q

What receptors does adrenaline show the highest affinity for?

A

A1, B1, B2 > A2

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15
Q

What receptors does NA show the highest affinity for?

A

A1 > B1, A2 > B2

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16
Q

Which drugs are selective A1 agonists? antagonist?

A

Agonist: Phenylephrine
Antagonist: Phentolamine

17
Q

What are the post-ganglionic receptors present in the parasympathetic nervous system?

A

Muscularinic

18
Q

Which catecholamine is most abundant in the blood?

A

Adrenaline

19
Q

Briefly outline noradrenaline synthesis

A

Tyrosine –> L-DOPA –> Dopamine –> Noradrenaline

20
Q

How does the botulism toxin prevent action potential generation?

A

Protease which cleaves snare proteins, preventing neurotransmitter vesicle release into the synaptic cleft

21
Q

Is adrenaline a neurotransmitter?

A

No, it is a hormone produced by the adrenal medulla

22
Q

What are the six steps of signal transduction?

A
  1. Recognition
  2. Transduction
  3. Transmission
  4. Modulation of an effector
  5. Response Termination

Cells to Systems (10 decks)

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