Reading

Question 1

Key points about the early promise of islet transplantation

Answer 1

1. The FDA voted to endorse pancreatic islet transplant product for treatment of brittle type1 diabetes that can’t be managed with current therapies.
2. They decided to regulate allogeneic islet cells as a biologic (1993).
3. Researcher’s from University of Illinois formed a company to file a biologics license application (BLA) to bring allo-islets to market.
4. Some in the transplant community feel allo-islets should be regulated as solid organs while granting BLA approval.

Question 2

Acute Lymphoblastic Leukaemia (ALL)

Answer 2

• A cancer of the blood and bone marrow.
• Acute = Progresses rapidly and creates immature blood cells (rather than mature).

Question 3

Tisagenleleucel (Kymriah)

Answer 3

CAR T-cell medication for treatment of B-cell ALL

Question 4

Cytokine release syndrome (CRS)

Answer 4

When your immune system responds to therapy or drugs more aggressively than it should

Question 5

Idecabtagene vicleucel

Answer 5

FDA-approved multiple myeloma therapy.
Targets B-cell maturation antigen (BCMA).