Activation of T-Helper Cells

Question 1

T-cell activation

Answer 1

1.Binding of MHC II (by TCR)
- strengthened by CD4
2.Binding of CD40 (by CD40L)
3.Binding of CD80/86 (by CD28)

Question 2

T-cell deactivation

Answer 2

1.Binding of MHC II (by TCR)
2.Binding of PDL1/2 (by PD1)
- strong inhibitory interaction
3.Binding of CD80/86 (by CTLA4)