Reabsorption In The Kidney

Question 1

How can you decribe reabsoprtion in the PCT?

Answer 1

Isosmotic, so that the ECF has the same osmotic pressure

Question 2

How is sodium reabosrbed in the PCT?

Answer 2

Na+ is pumped across the basolateral membrane by 3Na+- 2K+ ATPase, Na+ moves across the luminal membrane down its conentration gradient using a membrane transporter or channel and water follows

Question 3

What are the sodium transporters found in the PCT?

Answer 3

Na-H antiporter, and a Na-glucose symporter

Question 4

What are the sodium transporters found in the loop of henle?

Answer 4

Na-K-2Cl symporter

Question 5

What are the sodium transporters found in the early DT?

Answer 5

Na-Cl symporter

Question 6

What are the sodium transporters found in the late DT and CD?

Answer 6

ENaC and RomK

Question 7

What does SGLUT transport?

Answer 7

Two Na+ ions + 1 glucose agaisnt the concentration gradinet

Question 8

What are some of the substances secreted in the tubule fluid?

Answer 8

Protons, potassium and organic anions and cations

Question 9

How would you estimate the glomeluar filtration rate?

Answer 9

GFR= (concentration in urine x volume in urine)/plasma concentration

Question 10

What is eGFR used for?

Answer 10

To estimate the creatinine clearnace

Question 11

How would you determine eGFR?

Answer 11

(140-age)x mass in kgxconstant(1.23)/serum creatinine