RBC/WBC Abnormal Morphology Flashcards
Identify. What are the arrows pointing at
Anaplasma marginale
Arrows pointing at marginal bodies
Identify. What are the inclusion bodies called?
Cytauxzoon felis
Signet rings.
Identify. What are the inclusion bodies called?
Cytauxzoon felis
Signet rings. Maltese crosses.
What’s this
Cytauxzoon felis
(Macrophage with shizonts)
What’s this
Babesia canis
Whats this
Babesia gibsoni
What’s this
Theileria
What’s this
Theileria
What’s this? Distinguishing feature?
Mycoplasma hemocanis
Grows on cells (rather than in cells)
Whats this?
Mycoplasma
What’s this
Anisocytosis (RBCs of unequal size)
What’s this
Macrocyte (increased diameter, increased volume)
Formed by:
- Incomplete maturation or skipped cell division
Significance
- Increased erythropoiesis –> releases larger, immature cells
What’s this?
Poikilocyte (irregular, variable shape)
What’s this
Codocytes (Hb surrounded by a ring of pallor)
Significance
- Regenerative anemia
What’s this
Eccentrocyte (formed by oxidative damage to RBC membrane and Hgb)
Significance
- Overwhelming exposure to oxidants
What’s this?
Echinocyte (formed by membrane changes - crenation, usually due to alkaline pH of glass)
Significance:
- Drying artefact
- Hyponatremic dehydration
What’s this?
Acanthocyte (spur cell)
Significance
Canine hemangiosarcoma
Hepatic/renal disorders
(budding fragmentation)
What’s this
Elliptocyte
Significance
Acquired
- Myelofibrosis
- Fe-deficiency anemia
Hereditary
- RBC membrane defects
- Normal in camelids!
What’s this
Keratocyte (notched cell with 1-2 horn like projections)
Significance
- Microangiopathy
- Intravascular coagulation (fibrin strands)
- Vasculitis
What’s this? Which cell is it often seen with (#1)
Pyknocyte (spheroidal cell with condensed Hb)
Often seen with eccentrocytes (#1)
Significance
- Overwhelming exposure to antioxidants (similar to HB anemias)
What’s this?
Shizocyte (triangular, comma-shaped or round)
Formed by intravascular trauma
Significance
- Microangiopathy
- Intravascular coagulation (fibrin strands)
- Vasculitis
Spherocyte
Spherocyte (spheroid, round, globoid cell)
Formed: by removal of membrane or defective membrane
Significance
- Immune mediated (macrophages removing membrane)
- Fragmentation (associated with acanthocytosis, shizocytosis, keratocytosis)
What’s this
Reactive lymphocyte
Lymphocytes that become large as a result of persistent antigen stimulation. Usually associated with chronic infections –? confirm this
What’s this
Banded neutrophil
- Associated with left shifts*
- Regenerative = segs > bands*
- Degenerative = bands > segs*
What’s this
Hypersegmented neutrophil
Significance
- Old neutrophil
- Steroids
- Delayed sample analysis
What’s this
Toxic neutrophil
Significance
- Associated with severe inflammatory disease
- Bacterial infections
- Also can be caused by noninfectious inflammatous disorders
Features:
- foamy cytoplasm
- dohle body: ER, RNA (cats)
- diffuse cytoplasmic basophilia
- toxic granules (horses)
- asynchronous nuclear maturation
What are common features in reactive lymphocytes
Increased cytoplasmic basophilia
Prominent Golgi zone
Hyperchromatic nuclei
Whats this? Which species is it important for?*
Basophilic stripping
Ribosomal RNA that isnt degraded
Significance
- Regenerative anemia in cows
- Canine lead poisoning
What’s this?
Hepatazoon
What’s this
Leukemia
What’s this
Ehrlichia (morula)
