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Clin Path > Malignant Neoplasia > Flashcards

Malignant Neoplasia Flashcards

1
Q

How can you tell if a round cell is malignant?

A

Round cells are abnormal - usually malignant!

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2
Q

What do round cells originate from

A

Spindle cells

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3
Q

Cytologic characteristics of round cells

(nucleated cellularity, cell arrangement, morphology, cell boundaries)

A
  • Nucleated cellularity: high (hypercellular)
  • Cell arrangement: individual
  • Morphology: round cell, round nuclei
  • Cell boundaries: distinct
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4
Q

Features of mast cell tumors

A
  • Round cell neoplasm
  • Pink, reddish-purple cytoplasmic granules (many granules = advanced maturity)
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5
Q

Stains for mast cell tumors *

A

*Regular blood stains dont always stain granules*

Use: Toulidine Blue

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6
Q

Features of melanomas

A
  • Round cell (can be spindle cell)
  • Green-black cytoplasmic granules
  • Location is key! –> interdigital and mouth lesions are malignant
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7
Q

You have found melonams on a dog’s shoulder and neck (no where else). Are these maligant?

A

No - malignant are interdigital and mouth lesions

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8
Q

Features of transmissible venereal tumors (TVT)

A
  • Round cell neoplasm
  • Aggregates of cytoplasmic vacuoles
  • Basophilic cytoplasm
  • Found in urogenital system - can spread elsewhere
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9
Q

Features of histiocytoma

A
  • Round cell neoplasm
  • Pale-clear cytoplasm
  • No granules, vacuoles
  • Usually in young adults, self-limiting (little intervention necessary)
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10
Q

Features of lymphomas

A
  • Round cell neoplasm
  • Vary in size
  • Basophilic cytoplasm
  • High N:C ratio (huge nucleus)
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11
Q

Features of plasmacytoma

A
  • Deeply basophilic cytoplasm
  • Eccentric nucleus
  • Perinuclear clear (golgi) zone
  • Frequently binucleated
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12
Q

Round cell neoplasms (6)

A
  1. Mast cell tumor
  2. Melanoma
  3. TVT
  4. Histiocytoma
  5. Lymphoma
  6. Plasmacytoma
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13
Q

Are criteria of malignancy relevant for epithelial neoplasms

A

Yes - can be benign or malignant

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14
Q

Cytologic features of epithelial neoplasms

(nucleated cellularity, arrangement, morphology, cell boundaries)

A
  • Nucleated cellularity: high (hypercellular) – good cell exfoliation
  • Cell arrangement: clusters/sheets
  • Morphology: round to polyhedral
  • Cell boundaries: distinct
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15
Q

Examples of benign epithelial neoplasm

A
  • Glandular: thyroid adenoma
  • Lining epithelium: papilloma
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16
Q

Examples of malignant epithelial neoplasms

A
  • Glandular: mammary adenocarcinoma
  • Lining epithelium: squamous cell carcinoma
17
Q

What type of neoplasm is this? Why?

A

Epithelial

  • Clusters of cells
  • Distinct boundaries
  • Round/polyhedral shape
  • High cellularity
18
Q

Are criteria of malignancy relevant for mesenchymal neoplasms

A

Yes - can be malignant or benign

19
Q

Cytologic features of mesenchymal neoplasms

(nucleated cellularity, arrangement, morphology, cell boundaries)

A
  • Nucleated cellularity: low
  • Cell arrangement: individual
  • Morphology: spindle (with tails)
  • Cell boundaries: indistinct
20
Q

Fibroma and leiomyoma are examples of which type of neoplasm

A

Benign mesenchymal neoplasm

21
Q

Fibrosarcoma, osteosarcoma, myxosarcoma are examples of which type of neoplasm

A

Malignant mesenchymal neoplasm

22
Q

What’s this? Why?

A

TVT (round-cell neoplasm)

  • Vacuoles
  • Basophilic cytoplasm
23
Q

This is what kind of neoplasm? Why?

A

Mesenchymal neoplasm

  • Low cellularity
  • Eosinophilic matrix
  • Individual cells
  • Spindle morphology
  • Indistinct cell boundaries
24
Q

What type of neoplasm? Why?

A

Mast cell

  • Pink/red granules
  • Round cell
25
Q

What type of neoplasm? Why?

A

Melanoma

  • Dark granules!
  • Round cell
26
Q

What type of neoplasm? Why?

A

Histiocytoma

  • Pale, clear cytoplasm
  • Lacks granules, vacuoles
  • Round cell
27
Q

What type of neoplasm? Why?

A

Lymphoma

  • High N:C ratio (big nucleus)
  • Basophilic cytoplasm
  • Round cell
28
Q

What type of neoplasm? Why?

A

Plasmacytoma

  • Perinuclear clear (golgi) zone
  • Eccentric nucleus
  • Deeply basophilic cytoplasm
  • Round cell

Clin Path (11 decks)

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