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HEMATOLOGY 1 > RBC PRODUCTION AND DESTRUCTION > Flashcards

RBC PRODUCTION AND DESTRUCTION Flashcards

1
Q

factors that will induce it to mature in such a way that it will eventually lead in the production of RBC.

A

chemokines or cytokines

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2
Q

what is the goal of hematopoiesis

A

combat/alleviate any problems that the body experiences

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3
Q

erythroid progenitor cells that the rbc develop in the bone marrow

A

burst-forming unit-erythroid (BFU-E)
colony-forming unit-erythroid (CFU-E).

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4
Q

youngest to oldest precursor

A

pronormoblast
basophilic normoblast
polychromatic normoblast
orthochromic normoblast
polychromatic erythrocyte or reticulocyte.

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5
Q

what do you call the old erythroid

A

polychromatic erythrocyte or reticulocyte stage

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6
Q

what color reflects abundant ribosomal RNA

A

blue

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7
Q

what color reflects when hemoglobin accumulates &
the RNA is degraded.

A

salmon pink

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8
Q

specified or locked in in a specific
lineage

A

Totipotential

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9
Q

immature rbcs will undergo

A

mitosis

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10
Q

main function of rbc

A

carry hemoglobin to (?) path which are high

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11
Q

purpose of hemoglobin

A

carry oxygen & release oxygen to tissues

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12
Q

Goal of precursors

A

gaining of its function or maturation.

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13
Q

they’re the ones in charge stockpiling the hemoglobin while developing

A

precursor

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14
Q

t/f: The more immature the cell is, the more larger the nucleus

A

true

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15
Q

Hemoglobin has a protein component your globin & heme component, combination of

A

protoporphyrin 9
iron

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16
Q
A
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17
Q

opposite of active chromatin/ clumped chromatin

A

Heterochromatin

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18
Q

is just a string or thread and spindle is your chromatin

A

DNA

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19
Q

building up mechanism, because the nucleus itself isn’t the one making the protein/hemoglobin

A

Proerythroblast

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19
Q

The one making hemoglobin or globin portion

A

ribosome

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19
Q

signify protein production

A

Large nucleus & large component of euchromatin

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19
Q

t/f: That unwound DNA is your heterochromatin

A

false

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20
Q

excluded nucleus

A

Pyrenocyte

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20
Q

In this early phase, there are still a lot of mRNA production wala pa kaayo ribosoemes

A

Proerythroblast

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21
Q

consumable cells

A

RBC

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22
Q

How can you say the cell is already a pronormoblast
from your colony forming units?

A

There is production of organelles that will lead to hemoglobin production

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23
Q

nc ratio of pronormoblast

A

8:1

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24
Q

what is the color of cytoplasm of pronormoblast and why?

A

dark blue due to concentration of ribosomes & RNA.

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25
Q

The pronormoblast undergoes mitosis & gives rise to

A

2 daughter pronormoblasts

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26
Q

begins to accumulate the components necessary for hemoglobin production.

A

pronormoblast

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27
Q

globin production begins

A

pronormoblast

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28
Q

nucleus will stain what color and why

A

blue because nucleus is acidic

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29
Q

basic stain gives what color

A

blue

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30
Q

acidic stain will give what color

A

red

31
Q

In the context of your cytoplasm, why is it dark blue?

A

There are a lot euchromatin and mRNA

32
Q

is the most immature phase

A

pronormoblast

33
Q

The chromatin begins to condense, revealing clumps along the periphery of the nuclear membrane and a few in the interior

A

BASOPHILIC NORMOBLAST

34
Q

nc ratio of basophilic normoblast

A

6:1

35
Q

chromatin color of basophilic normoblast

A

deep purple-red

36
Q

chiefly for hemoglobin production

A

mRNA

37
Q

N:C ratio of polychromatic normoblast

A

4:1

38
Q

Notably, no nucleoli are present.

A

polychromatic normoblast

39
Q

color of polychromatic normoblast

A

pink

40
Q

why is the polychromatic normoblast pink

A

decreasing amounts of RNA.

41
Q

This is the last stage in which the cell is capable of undergoing mitosis,

A

polychromatic normoblast

42
Q

is a protein in the human body and it is more basic because of the amount of amino acids.

A

Hemoglobin

43
Q

nc ratio of orthochromic normoblast

A

1:2

43
Q

reflects nearly complete hemoglobin production.

A

orthochromic normoblast

44
Q

color of orthochromic normoblast

A

salmon pink

44
Q

not capable of division because of the condensation of the chromatin.

A

orthochromic normoblast

45
Q

Late in the stage, the nucleus is ejected from the cell

A

orthochromic normoblast

46
Q

there is no nucleus.

A

polychromatic erythrocyte

47
Q

how long does the polychromatic erythrocyte resides in the bone marrow

A

1 to 2 days

47
Q

the cell is the same color as a mature RBC

A

salmon pink, polychromatic erythrocyte

47
Q

how long does the polychromatic erythrocyte resides in the bone marrow

A

1 day before reaching maturity.

48
Q

digests the ribosomes.

A

Endoribonuclease

48
Q

We will only call it reticulocyte when we stain it with

A

supravital stain

49
Q

completes production of hemoglobin from a small amount
of residual messenger RNA using the remaining ribosomes

A

polychromatic erythrocyte

50
Q

what cells do supravital stain stains?

A

live cells

51
Q

there are still reticulum left which is composed of RNA

A

reticulocyte

52
Q

stain used in erythrocyte

A

Wright-stained blood film

53
Q

life span of rbc

A

120 days

54
Q

Aging of rbc leads to their removal by what organ

A

spleen

55
Q

spherical rbc/circle shape

A

hard time transferring your gasses

56
Q
A
57
Q

donut shape rbc

A

gas transfer is faster

58
Q

the ability to traverse through tight curvices, tight blood vessels

A

Deformability

59
Q

how many days for the BFU-E to mature to an RBC

A

18 to 21

60
Q

how many days are spent as identifiable precursors in the
bone marrow.

A

6 days

61
Q

what organ who produces EPO

A

kidney

62
Q

a hormone that stimulates production and survival of red
blood cells

A

Erythropoietin

63
Q

transmembrane receptor that stimulate apoptosis

A

Fas receptor

64
Q

cells give iron to the red blood cells.

A

nurse cells

65
Q

red blood cell precursor get iron is from, a soluble transport type of your iron

A

transferrin

66
Q

primary hormone that stimulates the production of erythrocytes,

A

EPO

67
Q

the ligand, is expressed by older erythroid precursors.

A

FasL

68
Q

increases hepcidin. Meaning, there is an increase in iron absorption.

A

Erythroferrone

69
Q

rescues CFU-E cells from apoptosis

A

EPO

70
Q

cannot regenerate catabolized enzymes because they lack a nucleus.

A

Aged RBCs

71
Q

accounts for most normal RBC deaths.

A

macrophage-mediated
hemolysis

71
Q

results when mechanical factors rupture the cell membrane while the cell is in the peripheral circulation.

A

intravascular hemolysis

71
Q

marker for phagocytosis

A

Phosphatidylserine

72
Q

This pathway accounts for a minorcomponent of normal destruction of RBCs

A

intravascular hemolysis

HEMATOLOGY 1 (6 decks)

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