Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMATOLOGY 1 > RBC ABNORMALITIES > Flashcards

RBC ABNORMALITIES Flashcards

1
Q

T/F: it provides an experienced observer with valuable information about morphology

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T/F: rbc abnormality importance suggests a particular disease, aids in diagnosis

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are of RBCs should be slightly separated from one another or barely touching without overlapping; should represent 1/3 of the entire film

A

thin area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are of RBCs may overlap or lie on top of one another, making them unsuitable

A

thicker portions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the ideal distribution of rbc

A

thin portion adjacent to the feather end of the film

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

not separated with each other; appear in short/long stacks resembling coins

A

rouleaux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

cells are in clusters or masses when exposed to antibodies

A

agglutination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

normal or in disease state (atypical pneumonia or hemolytic anemia)

A

autoagglutination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

clumping at below 25 celsius; increased mcv in automated machine- (artifactual) since clumps are counted as one

A

cold agglutinin disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

T/F: central pallor of rbc should be more than 1/3 of the cell

A

FALSE dapat not more than 1/3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

clear central pallor (1/3)

A

normochromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q
  • increasing central pallor, decreasing hgb concentration
  • caused by impaired hb synthesis
  • associated most often with microcytosis; (e.g. IDA, thalassemia,sideroblastic anemia)
A

hypochromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q
  • lack of central pallor associated with macrocytosis
  • mchc is elevated in true hyperchromia
  • hemolytic anemia including hemolysis caused by burns
A

hyperchromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

premature released cells occurs as a result of stimulated erythropoiesis

A

shift cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

rbc size that is correlated with MCV:
- if diameter exceeds 8.5-9um and MCV exceeds 100fL
- low vitamin b12, alcoholism with or without liver disease, cancer chemotheraphy, chronic HA with reticulocytosis, myeloma etc.
- diffusely basophilic occurs as a result of stimulated erythropoiesis

A

normocytic
macrocytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

rbc size that is correlated with MCV:
- small rbc, occurs when mcv is below 80fL
- characteristic of IDA

A

microcytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

lack central pallor and appear to have increased Hb seen in hemolytic anemia

A

spherocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

thinner than normal and have a colorless center; increased surface area that is out of the proportion to the volume

A

leptocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q
  • describes red blood cells that are of different sizes.
  • shows variation in population size or diameter in the blood
A

anisocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

T/F: red cell distribution width is an estimate of erythrocyte variation in sizes, calculated in most automated analyzers, and is used as index of red cell population homorogeneity

A

FALSE - dapat heterogeneity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q
  • large oval shaped cells with marked increased mcv
  • occur due to nuclear maturation defect in the early marrow cells caused by vit b12 or folate deficiency; strongly suggest MEGALOBLASTIC ANEMIA
  • > 125fL ; size: > 7 Hg
A

oval macrocytes

19
Q
  • elliptical egg-shaped/oval to sausage shaped
  • seen in hereditary elliptocytosis, IDA, MMM
A

elliptocytes

20
Q
  • round, small redcells, lacks central pallor, showing an intense staining affinity
  • h or a, seen in HS, acquired HA, burned patient
A

spherocyte

20
Q
  • central area of Hb surrounded by a relatively colorless ring, appear like a bell or tall hat shaped, or mexican hat shell
  • membrane surface is increased after loading of the membrane with cholesterol and phospholipids
A

codocytes

21
Q

having many uniform tiny spicules on their surfaces; represent artifact on films; should not be reported

A

echinocytes

22
Q
  • having irregularly sized and unevenly spaced spicules, that differs from echinocytes, and should be reported when seen
  • related to increase in bun
A

burr cells

23
Q
  • small, densely stained rbcs having few irregular, large pointed spicules or thorn like projections
  • caused by changes in ratio of plasma lipids
  • abetalipoproteinemia, alcoholic cirrhosis with HA
A

acanthocytes

24
Q
  • having an elongated or slit like area of central pallor (mouth shaped)
  • H or A membrane defect in the Na+: K+ transport ratio and a greatly increased rate of active cation trn
  • alcoholism, cirrhosis, obstructive liver disease, Rh null disease
A

stomatocytes

25
Q

T/F: poikilocytes are primary to trauma

A

FALSE - secondary

26
Q
  • aka helmet cells
  • undergoes cleavage and fragmentation
  • process is associated with either small blood vessel disease or fibrin in small blood vessel and results in intravascular fragmentation
  • MAHA, severe burns, renal graft rejection, glumerulonephritis, vasculitis
A

schistocytes

27
Q
  • a schistocyte with one or more horn like projections; a rare phenomenon; should be reported as schistocyte
  • a result of rbc being caught on a fibrin strand w/c could cut it to two. when this escapes, it may have a vacoule like area (blister cell) - associated with g6pd
A

keratocyte

28
Q
  • teardrop or pear shaped cells
  • rbc containing heinz bodies that squeeze through the spleenic sinuses, hence, will have its original shaped stretched
  • seen in MMM, heinz body anemia, myelophthisic anemia
A

dacrocytes

29
Q
  • usually seen in severe burns as small, round cells, as a result of thermal damage to the membrane
  • rare hereditary HA associated with heat sensitivity at 45 celsius
A

microspherocytes

30
Q
  • large fragments of red cell membrane with their contents being extruded, and stain pale pink forming a half moon or crescent shape cell
  • frequently seen in malaria
A

drepanocytes

30
Q

intracellular hexagonal crystals with blunt ends and strains darkly; forms within the red cell membrane when hb c crystallizes

A

hemoglobin cc crystals

30
Q

small round fragments of a metarubricyte and stain reddish blue in wright’s; result from kharyorrhexis or from incomplete extrusion of nucleus during mitosis, give positive feulgen reaction

A

howell-jolly bodies

31
Q
  • dark-hued crystals of condensed hb that distorts rbc membrane
  • one or more fingerlike blunt pointed projections, that protrude from the cell membrane in different directions
A

hemoglobin sc crystals

32
Q

two forms of basophilic stippling

A

fine stippling
granular stippling

33
Q

irregularly shaped basophilic granules; represents aggregates of ribosomes

A

basophilic stippling

34
Q

stippling due to increased red cell population, seen with increased polychromatophilia

A

fine stippling

35
Q

stippling due to abnormal instability of RNA in the young cells, seen in lead poisoning, thalassemia, megaloblastic anemia, and severe anemia

A

granular stippling

35
Q

small irregular dark staining granules located in the periphery; positive with prussian blue

A

pappenheimer bodies

36
Q

heinz bodies is best stained with

A

supravital stain

36
Q
  • round refractile bodies of denatured hemoglobin precipitates, not visible in wrights stain; pitted golf apperance if multiple
  • seen in hereditary g6pd deficiency
A

heinz bodies

37
Q
  • small greenish-blue inclusion bodies
  • precipitated hb h
  • a-thalassemia
A

hemoglobin H inclusions

37
Q

an oxidant used in heinz bodies for a long period induces heinz body formation

A

acetylphenylhydrazine

38
Q

plasmodium spp transmitted to man by anopheles mosquito

A

malaria

39
Q

schuffner’s stippling, four maturation stages infects the rbc-enlarged

A

p. vivax

39
Q

protozoan inclusion that is the same but rbc is not enlarged

A

p. malariae

40
Q

small delicate ring froms, gametocytes are banana shaped

A

p. falciparum

41
Q

rbc is oval, schuffners stippling is present

A

p. ovale

42
Q
  • rare transmission to humans by tick bites
  • resemble ring stages of malarial parasites
  • tiny rings 1-5um
  • tetrad formation
  • rbc not enlarged
A

babesia microti

HEMATOLOGY 1 (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions