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Heme./Onc > RBC Metabolism > Flashcards

RBC Metabolism Flashcards

1
Q

What is the key marker for intravascular hemolysis?

A

hemoglobin

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2
Q

What is the key marker for extravascular hemolysis?

A

bilirubin

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3
Q

What protein can reduce hemoglobin? What does this enzyme use as a reducing equivalent?

A

Methemoglobin reductase

NADH

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4
Q

What protein in RBCs keep sulfhydryl groups reduced?

A

glutathione

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5
Q

Does a high or low pH inhibit hexokinase and PFK?

A

low

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6
Q

What is the substrate for the energy clutch?

A

1,3-bisphosphoglycerate

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7
Q

What is the intermediate of the energy clutch?

A

2,3-bisPhosphoglycerate

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8
Q

What is the end product of the energy clutch?

A

3-phosphoglycerate

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9
Q

Does a low or high pH inhibit the synthesis of 2,3-BPG?

A

low = inhibits

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10
Q

What does pyruvate kinase deficiency cause?

A

hemolytic anemia

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11
Q

What are the two mechanisms by which HIF1α is active in cancer cells?

A
  1. increases txn of glucose transporters

2. decreases activity of PDH

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12
Q

What attacks cells during PNH? Which cells?

A

complement

RBCs, granulocytes, platelets

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13
Q

Which direction does potassium move when a red cell lyses?

A

potassium = out

calcium = in

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14
Q

Does the energy clutch happen is the pH drops or rises?

A

drops

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15
Q

What are the two regulated steps of glycolysis in RBCs?

A

hexokinase

PFK1

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16
Q

Does an acidic pH inhibit or promote glycolysis?

A

inhibit

17
Q

Is 2,3-BPG synthesis inhibited at high or low pH?

A

low pH

18
Q

Deficiency in what two enzymes can cause a hemolytic anemia?

A

pyruvate kinase

G6PDase

19
Q

What is the mechanism of inheritance for G6PDase deficiency?

A

X-linked recessive

20
Q

Expression of what tx factor is upregulated in neoplastic cells? What is the function of this txn factor?

A

HIF-1α

promote anaerobic metabolism

21
Q

Does AIP of PCT produce photo sensitivity?

A

PCT

22
Q

According to Schmidt, defects in RBC metabolism can produce extravascular or intravascular hemolysis?

A

both

23
Q

What metabolite is produced in excess by tumor cells? Where is this metabolite shunted?

A

lactate

Cori cycle

24
Q

What protein can oxidize iron from Fe2+ to Fe3+?

A

Hephaestin

Heme./Onc (15 decks)

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