Hilgerson Hemolytic Anemia Flashcards

1
Q

Is microangiopathic hemolytic anemia intravascular or extravascular?

A

intra

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2
Q

Is babesiosis/malaria intra or extra?

A

intra

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3
Q

Is PNH intra or extra?

A

intra

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4
Q

Is warm agglutinin intra or extravascular hemolysis?

A

extra

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5
Q

Is cold agglutinin intra or extravascular hemolysis?

A

intra

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6
Q

Is HbS intra or extra?

A

extra

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7
Q

Are G6PDase and PK intra or extra hemolysis?

A

extra

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8
Q

Is haptoglobin increased or decreased during hemolytic anemia?

A

decreased

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9
Q

Is LDH elevated or decreased in hemolytic anemia?

A

increased

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10
Q

Is reticulocyte count increased or decreased during hemolytic anemia?

A

increased

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11
Q

Is indirect bilirubin increased or decreased during hemolytic anemia?

A

increased

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12
Q

Is hemosiderin high or low in the urine during hemolytic anemia?

A

high

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13
Q

What is the mode of inheritance of G6PDase deficiency?

A

X-linked recessive

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14
Q

In what two populations is the liklihood of G6PDase deficiency increased?

A

African of Mediterranean

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15
Q

What is notable about the urine of HbS patient?

A

often they cannot concentrate their urine

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16
Q

Name two bacteria for Salmonella? Especially?

A

encapsulated

Salmonella

17
Q

What is the renal pathology of HbS?

A

renal papillary necrosis

18
Q

What is the mode of inheritance of hereditary spherocytosis? What population?

A

Autosomal dominant

Northern europeans

19
Q

Why can extravascular hemolysis cause gall stones?

A

increased unconjugated bilirubin due to extravascular hemolysis

20
Q

What is the treatment of hereditary spherocytosis?

A

folate supplementation

21
Q

What is the triad of PNH?

A

hemolysis

pancytopenia

risk for thrombosis

22
Q

Other than steroids, what is the Tx for PNH? What is the MOA of this drug? What specific protein?

A

eculizimab

complement inhibitor

C5

23
Q

What four drugs are known to cause drug-induced hemolytic anemia?

A

penicillin, quinidide, methyldopa, cephalosporin

24
Q

What two viral immunizations are patients with HbS given?

A

EBV and flu