Hilgerson Hemolytic Anemia Flashcards
Is microangiopathic hemolytic anemia intravascular or extravascular?
intra
Is babesiosis/malaria intra or extra?
intra
Is PNH intra or extra?
intra
Is warm agglutinin intra or extravascular hemolysis?
extra
Is cold agglutinin intra or extravascular hemolysis?
intra
Is HbS intra or extra?
extra
Are G6PDase and PK intra or extra hemolysis?
extra
Is haptoglobin increased or decreased during hemolytic anemia?
decreased
Is LDH elevated or decreased in hemolytic anemia?
increased
Is reticulocyte count increased or decreased during hemolytic anemia?
increased
Is indirect bilirubin increased or decreased during hemolytic anemia?
increased
Is hemosiderin high or low in the urine during hemolytic anemia?
high
What is the mode of inheritance of G6PDase deficiency?
X-linked recessive
In what two populations is the liklihood of G6PDase deficiency increased?
African of Mediterranean
What is notable about the urine of HbS patient?
often they cannot concentrate their urine
Name two bacteria for Salmonella? Especially?
encapsulated
Salmonella
What is the renal pathology of HbS?
renal papillary necrosis
What is the mode of inheritance of hereditary spherocytosis? What population?
Autosomal dominant
Northern europeans
Why can extravascular hemolysis cause gall stones?
increased unconjugated bilirubin due to extravascular hemolysis
What is the treatment of hereditary spherocytosis?
folate supplementation
What is the triad of PNH?
hemolysis
pancytopenia
risk for thrombosis
Other than steroids, what is the Tx for PNH? What is the MOA of this drug? What specific protein?
eculizimab
complement inhibitor
C5
What four drugs are known to cause drug-induced hemolytic anemia?
penicillin, quinidide, methyldopa, cephalosporin
What two viral immunizations are patients with HbS given?
EBV and flu