Hemostasis

Question 1

What is the receptor for collagen?

Answer 1

integrin α2β1

Question 2

What three hormones are found in dense granules?

Answer 2

histamine, serotonin, epinephrine

Question 3

What are the four constituents of α-granules?

Answer 3

vWF, fibrinogen, fibronectin, Factor V

Question 4

What two clotting factors are released by desmopressin?

Answer 4

vWF and VIII

Question 5

What bleeding disorder can have giant platelets?

Answer 5

Bernard-Soulier

Question 6

What is the function of gamma-carboxyglutamate?

Answer 6

bind calcium for clotting

Question 7

What clotting factor activates Factor XIII? What type of enzymatic activity does this clotting factor possess?

Answer 7

thrombin

transglutaminase

Question 8

Factor XIII connects which two amino acids? Via what bond?

Answer 8

lysine and glutamine

amide

Question 9

What is the mode of inheritance for Hemophilia A and B?

Answer 9

X-linked recessive

Question 10

What type of molecule is Antithrombin III?

Answer 10

Serpin

Question 11

TFPI inhibits which two coagulation cascade proteins?

Answer 11

VIIa and Xa

Question 12

What stimulates the release of tPA?

Answer 12

Activated Protein C

Question 13

Which two proteins directly inhibit plasmin?

Answer 13

α2-antiplasmin

α2-macroglobulin

Question 14

What protein does streptokinase activate?

Answer 14

plasminogen

Question 15

What is the first prostaglandin involved in clotting? Second? Final?

Answer 15

first = G2

second = H2

third = TXA2

Question 16

Does serotonin release from platelets act to vasoconstrict or vasodilate?

Answer 16

vasoconstrict

Question 17

What two clotting factors does thrombin activate?

Answer 17

five and eight

Question 18

Regarding coagulation, what is the function of kallikrein?

Answer 18

activate additional factor twelve

Question 19

β-hemolytic streptococci provides what plasminogen activator?

Answer 19

streptokinase

Question 20

What cell type releases TFPI?

Answer 20

endothelial

Question 21

According to Wilson, what three coagulation factors require thrombin for their activation?

Answer 21

five, “seven” and eight

Question 22

What protein does APC inactivate?

Answer 22

plasinogen activator inhibitor

Question 23

Other than plasmin, tPA has a high affinity for what protein?

Answer 23

fibrin

Question 24

What is the most common platelet/clotting disorder ? How is this disease often identified?

Answer 24

vWF disorder

dental work

Question 25

Which clotting factors are stable when bound to cell membrane?

Answer 25

seven, nine and ten

Question 26

What amino acid substitution is present in Factor V Leiden disease?

Answer 26

arginine to glutamine