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Heme./Onc > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

What is the lifespan of platelets?

A

7 - 10 days

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2
Q

What is the lifespan of granulocytes?

A

6 - 8 hours

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3
Q

What cell does G-CSF promote the formation of?

A

Granulocytes

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4
Q

What cell does IL-3 promote the formation of?

A

basophil

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5
Q

What cell does IL-5 promote the formation of?

A

Eosinophil

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6
Q

What cell does M-CSF promote the formation of?

A

monocyte

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7
Q

Which two interluekins are especially important in the thymus?

A

IL2 and IL7

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8
Q

Which interleukin promotes the formation of B-cells?

A

IL-7

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9
Q

Which interleukin promotes the formation of NK cells?

A

IL-15

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10
Q

G-CSF can be released by what cell type? Where?

A

macrophages

sites of inflammation

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11
Q

What specific cell of the kidney can produce EPO? What triggers this event?

A

peritubular interstitial cell

hypoxia

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12
Q

What drug induces a mobilization of bone marrow stem cells to the peripheral circulation?

A

G-CSF

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13
Q

GM-CSF stimulates the recovery of what cell type? What is the draw back of GM-CSF?

A

Myeloid

more toxic than G-CSF

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14
Q

What two places can extramedullary hematopoiesis take place?

A

spleen and liver

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15
Q

What is another name for a rubriblast? Does this cell stain basophilic or acidophilic?

A

pro-erythroblast

basophilic

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16
Q

What cell type comes after a rubriblast?

A

Prorubricyte

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17
Q

What cell type comes after a prorubricyte?

A

rubricyte

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18
Q

What cell type comes after a rubricyte?

A

Metarubricyte

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19
Q

What cell type comes after a metarubricyte?

A

Reticulocyte

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20
Q

What does the reddish pink stain of an erythrocyte indicate?

A

hemoglobinization is complete

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21
Q

What is the first cell of granulopoiesis?

A

stem cell

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22
Q

What cell type comes after a stem cell during granulopoiesis?

A

myeloblast

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23
Q

What cell type comes after a myeloblast?

A

promyelocyte

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24
Q

What cell type comes after a promyelocyte?

A

myelocyte

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25
Q

What cell type comes after a myelocyte?

A

metamyelocyte

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26
Q

What cell type comes after a metamyelocyte?

A

band cell

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27
Q

What are macrophages in loose connective tissue called?

A

Histiocytes

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28
Q

What are macrophages in liver cells called?

A

Kupffer cells

29
Q

What are macrophages in the CNS called?

A

microglial cells

30
Q

Where do B lymphocytes and NK cells develop?

A

bone marrow

31
Q

At what stage in their development do T-cells leave the bone marrow?

A

Prothymocytes

32
Q

What is the most immature lymphocyte called?

A

lymphoblast

33
Q

What comes after a lymphoblast?

A

prolymphocyte

34
Q

What comes after a prolymphocyte?

A

Lymphocyte

35
Q

What is the most immature platelet precursor?

A

Megakaryoblast

36
Q

What cell comes after a megakaryoblast?

A

Promegakaryocyte

37
Q

What comes after a promegakaryocyte ?

A

Megakaryocyte

38
Q

What is a number cell count for leukocytes?

A

4.5 - 11 x 10x3

39
Q

What is a normal RBC count in males?

A

4.3-5.7 x10x3

40
Q

What is a normal RBC count in females?

A

3.8 - 5.1 x10x3

41
Q

What cytokine can down-regulate stem cell growth/differentiation?

42
Q

In an adult, what are the three locations where bone marrow is found?

A

ribs, sternum and pelvis

43
Q

Approximately how long do monocytes circulate before entering tissues?

44
Q

At what stage of development do lymphocytes enter the thymus?

A

Prolymphocytes

45
Q

What is the first cell differentiate for macrophages?

46
Q

What comes after a monoblast?

A

promonocyte

47
Q

What comes after a promonocyte?

48
Q

What is the first cell to differentiate for a B-cell or T-cell?

A

lymphoblast

49
Q

What comes after a lymphoblast?

A

prolymphocyte

50
Q

What comes after a prolymphocyte?

A

lymphocyte

51
Q

What is a normal band cell percentage count?

52
Q

What two free radicals can copper or iron produce in the fenton reaction?

A

superoxide or hydroxyl radical

53
Q

What oxidation state is iron found in plants?

54
Q

What does TIBC measure?

A

unoccupied transferrin

55
Q

What is the most common inherited bleeding disorder?

A

von willebrand deficiency

56
Q

Other than giant platelets, what does Bernard-Souiler syndrome often present with?

A

thrombocytopenia

57
Q

What is the mode of inheritance for hemophilia?

A

X-linked recessive

58
Q

How long does it take for reticulocytes to increase in their count and appear in blood?

59
Q

According to Hilgerson, which immunoglobulin attacks RBC membrane proteins?

60
Q

According to Hilgerson, does a warm or cold agglutinin test procude a positice coombs test?

61
Q

According to hilgerson, which AIHA is treated with corticosteroids?

62
Q

According to Wendy-Woods Swafford, where do arterial thrombi occur?

A

sites of endothelial injury

63
Q

According to Yost, what are the three causes of thrombocytopenia?

A

under-production

destruction

splenic sequestration

64
Q

According to Yost, pernicious anemia can present with what other hematological issue?

A

20% thrombocytopenia

65
Q

What are four ways ITP is treated?

A

steroids

IV-IG

rituximab

SPLENECTOMY

66
Q

How many days after infusion can HIT begin to produce symptoms?

67
Q

Drugs that cause thrombocytopenia affect what cause?

A

under-production

68
Q

Underproduction affects a minimum of how many cell lines?

A

at least two

69
Q

What is the most common cause of thrombocytopenia in children and adults?

A

immune thrombocytopenia

Heme./Onc (15 decks)

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