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Heme./Onc > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

What is the lifespan of platelets?

A

7 - 10 days

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2
Q

What is the lifespan of granulocytes?

A

6 - 8 hours

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3
Q

What cell does G-CSF promote the formation of?

A

Granulocytes

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4
Q

What cell does IL-3 promote the formation of?

A

basophil

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5
Q

What cell does IL-5 promote the formation of?

A

Eosinophil

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6
Q

What cell does M-CSF promote the formation of?

A

monocyte

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7
Q

Which two interluekins are especially important in the thymus?

A

IL2 and IL7

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8
Q

Which interleukin promotes the formation of B-cells?

A

IL-7

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9
Q

Which interleukin promotes the formation of NK cells?

A

IL-15

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10
Q

G-CSF can be released by what cell type? Where?

A

macrophages

sites of inflammation

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11
Q

What specific cell of the kidney can produce EPO? What triggers this event?

A

peritubular interstitial cell

hypoxia

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12
Q

What drug induces a mobilization of bone marrow stem cells to the peripheral circulation?

A

G-CSF

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13
Q

GM-CSF stimulates the recovery of what cell type? What is the draw back of GM-CSF?

A

Myeloid

more toxic than G-CSF

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14
Q

What two places can extramedullary hematopoiesis take place?

A

spleen and liver

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15
Q

What is another name for a rubriblast? Does this cell stain basophilic or acidophilic?

A

pro-erythroblast

basophilic

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16
Q

What cell type comes after a rubriblast?

A

Prorubricyte

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17
Q

What cell type comes after a prorubricyte?

A

rubricyte

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18
Q

What cell type comes after a rubricyte?

A

Metarubricyte

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19
Q

What cell type comes after a metarubricyte?

A

Reticulocyte

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20
Q

What does the reddish pink stain of an erythrocyte indicate?

A

hemoglobinization is complete

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21
Q

What is the first cell of granulopoiesis?

A

stem cell

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22
Q

What cell type comes after a stem cell during granulopoiesis?

A

myeloblast

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23
Q

What cell type comes after a myeloblast?

A

promyelocyte

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24
Q

What cell type comes after a promyelocyte?

A

myelocyte

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25
What cell type comes after a myelocyte?
metamyelocyte
26
What cell type comes after a metamyelocyte?
band cell
27
What are macrophages in loose connective tissue called?
Histiocytes
28
What are macrophages in liver cells called?
Kupffer cells
29
What are macrophages in the CNS called?
microglial cells
30
Where do B lymphocytes and NK cells develop?
bone marrow
31
At what stage in their development do T-cells leave the bone marrow?
Prothymocytes
32
What is the most immature lymphocyte called?
lymphoblast
33
What comes after a lymphoblast?
prolymphocyte
34
What comes after a prolymphocyte?
Lymphocyte
35
What is the most immature platelet precursor?
Megakaryoblast
36
What cell comes after a megakaryoblast?
Promegakaryocyte
37
What comes after a promegakaryocyte ?
Megakaryocyte
38
What is a number cell count for leukocytes?
4.5 - 11 x 10x3
39
What is a normal RBC count in males?
4.3-5.7 x10x3
40
What is a normal RBC count in females?
3.8 - 5.1 x10x3
41
What cytokine can down-regulate stem cell growth/differentiation?
TGF-beta
42
In an adult, what are the three locations where bone marrow is found?
ribs, sternum and pelvis
43
Approximately how long do monocytes circulate before entering tissues?
8 hours
44
At what stage of development do lymphocytes enter the thymus?
Prolymphocytes
45
What is the first cell differentiate for macrophages?
Monoblast
46
What comes after a monoblast?
promonocyte
47
What comes after a promonocyte?
monocyte
48
What is the first cell to differentiate for a B-cell or T-cell?
lymphoblast
49
What comes after a lymphoblast?
prolymphocyte
50
What comes after a prolymphocyte?
lymphocyte
51
What is a normal band cell percentage count?
3-5%
52
What two free radicals can copper or iron produce in the fenton reaction?
superoxide or hydroxyl radical
53
What oxidation state is iron found in plants?
Fe3+
54
What does TIBC measure?
unoccupied transferrin
55
What is the most common inherited bleeding disorder?
von willebrand deficiency
56
Other than giant platelets, what does Bernard-Souiler syndrome often present with?
thrombocytopenia
57
What is the mode of inheritance for hemophilia?
X-linked recessive
58
How long does it take for reticulocytes to increase in their count and appear in blood?
5 days
59
According to Hilgerson, which immunoglobulin attacks RBC membrane proteins?
IgG
60
According to Hilgerson, does a warm or cold agglutinin test procude a positice coombs test?
warm
61
According to hilgerson, which AIHA is treated with corticosteroids?
warm
62
According to Wendy-Woods Swafford, where do arterial thrombi occur?
sites of endothelial injury
63
According to Yost, what are the three causes of thrombocytopenia?
under-production destruction splenic sequestration
64
According to Yost, pernicious anemia can present with what other hematological issue?
20% thrombocytopenia
65
What are four ways ITP is treated?
steroids IV-IG rituximab SPLENECTOMY
66
How many days after infusion can HIT begin to produce symptoms?
5-14 days
67
Drugs that cause thrombocytopenia affect what cause?
under-production
68
Underproduction affects a minimum of how many cell lines?
at least two
69
What is the most common cause of thrombocytopenia in children and adults?
immune thrombocytopenia

Heme./Onc (15 decks)

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