RBC Disorders Flashcards
Anemia is defined as a decrease in:
Rbc
Hgb
Hct
Leading to DEC O2 delivery to tissues
Initial lab tests for diagnosis of anemia
Cbc, reticulocyte count, peripheral blood smear
Classification of anemia where production of erythroid precursors are defective
Ineffective erythropoiesis
Megaloblastic anemia
Thalassemia
Sideroblastic anemia
Myelodysplastic syndrome
Classification of anemia where the number of erythroid precursor in the bone marrow is decreased
Insufficient erythropoiesis
IDA
Anemia due to renal diseases
Aplastic anemia
Sarcoidosis
Acute leukemia
Most common form of anemia
Iron deficiency anemia
(nutritional anemia)
Koilonychia and pica can be seen on patients with ____________
Iron deficiency anemia
Second most common type of anemia and most common type of anemia in hospitalized patients (nosocomial anemia)
Anemia of chronic disease / Inflammation
Type of anemia that has the inability to use available iton for Hgb production
Anemia of chronic disease / inflammation
Sideroblastic anemia is caused by…
Blocks protoporphyrim pathway = defective Hgb synthesis + iron overload
In sideroblastic anemia, excess iron ___________ in the ______________ of the immature RBCs in the BM and encircles the nucleus.
Accumulates
Mitochondrial region
*this is called ringed sideroblasts *
if accumulation in mature RBCs = ringed siderocytes
Chronic exposure to lead will make the RBC morphology: ____________
Microcytic, hypochromic
It inhibits ferrochelatase and D-ala synthase enzyme in Heme/Protoporphyrin pathway
Anemia due to lead poisoning
Megaloblastic anemia is a ___________ [ ineffective, insufficient ] erythropoiesis
Ineffective
