RBC Abnormalities

Question 1

Variation in RBC size is…

Answer 1

Aniocytosis

Question 2

Normocytic RBC’s size and MCV

Answer 2

6-8um
80-100fL

Question 3

Variation in hemoglobin content is…

Answer 3

Anisochromia

Question 4

Spherocytosis occurs when there is an _______ (INC, DEC) MCHC

Answer 4

Increased

Question 5

Variation in RBC cell shape

Answer 5

Poikilocytosis

Question 6

Red cell with irregular spikes: ____________
Red cell with regular scalloped short projections: _____________

Answer 6

Acanthocyte/Spur cell/Thorn cell

Echinocyte/Burr/Sea urchin/ Crenated cells

Question 7

Describe target cell/codocyte/mexican hat cell

Answer 7

Peripheral rim of Hb surrounded by clear area and central hemoglobinized area

Resemble shooting target (bull’s eye)

Excessive ratio of membrane lipid to cell volume

Seen in hemoglobinopathies

Question 8

Abnormal red cell that lacks central pallor

Answer 8

Spherocyte or bronze cells

Question 9

Abnormal red cell that is elongated or has a slit-like area

Answer 9

Stomatocytes

mouth-like appearance
INC Na ions, DEC K ions

Question 10

Cigar shaped, narrower than ovalocytes

Answer 10

Elliptocytes

Question 11

Abnormal cells that are present on Gerbich null disease

Answer 11

Elliptocyte

Question 12

Abnromal cell with Bipolar arrangement in hemoglobin with reduction in membrane cholesterol

Answer 12

Ovalocyte

egg-like or oval-shaped

Question 13

Poikilocytes secondary to trauma

Answer 13

Schistocyte
Dacrocyte (Tear drop cell)
Pyropoikilocytes
Semilunar bodies/Half moon

Question 14

Which abnormal RBC fragment at 45deg C?

Answer 14

Pyropoikilocytes

Question 15

Abnormal RBC that fragments from prosthetic heart valves

Answer 15

Schistocyte /Schiztocyte

Question 16

Poikilocyte that is caused by polymeration of deoxygenated Hgb

Answer 16

Drepanocytes / Sickle Cell Menisocytes

Question 17

Red cell present on “Holy leaf formation”

Answer 17

Schistocyte / Schiztocyte

Question 18

Rbc inclusion resulting from karyorrhexis

Answer 18

Howell joy bodies

Question 19

Blue berry bagel appearance

Answer 19

Basophilic stippling / Punctuate basophilia

Question 20

Rbc inclusion: Remnants of microtubules of mitotic spindle

Answer 20

Cabot rings

Question 21

Rbc inclusion: from precipitated denatured Hgb due to oxidative injuries

Answer 21

Heinz bodies

Question 22

Multiple heinz bodies may give a cell appearance of….

Answer 22

Pitted golf ball

Question 23

Pappenheimer bodies are…

Answer 23

Unused iron deposits

Question 24

Rbc inclusion: hexagonal w/ blunt ends and stain darkly

Answer 24

Hb C or CC Crystals

Barr of Gold / Clam Shell appearance

Question 25

Rbc inclusion: Crystalline finger-like / quartzlike crystals

Answer 25

Hb SC crystals

Washington monument crystal

Question 26

Rbc inclusion: Excessive iron overload in mitochondria of normoblast

Answer 26

Ringed sideroblast

Question 27

Malarial inclusions:

P.malariae
P.ovale
P. vivax
P.falciparum

Answer 27

Ziemann’s dot
James dot
Schuffner’s dot
Maurer’s dot

Question 28

Rouleaux formation is due to…..

Answer 28

Abnormal or INC plasma proteins

Question 29

Rbc fragment in a shape of a helmet

Answer 29

Keratocyte

Question 30

Blister cells are erythrocytes containing….

Answer 30

One or more vacuoles that resemble blister on skin

vacuoles may rupture producing: keratocytes or schistocytes.

Question 31

Blister cells result from…

Answer 31

Traumatic interaction of blood vessels and circulating blood

Question 32

Abnormal rbc that resemble pinched bottle

Answer 32

Knizocyte