RBC Abnormalities Flashcards
Variation in RBC size is…
Aniocytosis
Normocytic RBC’s size and MCV
6-8um
80-100fL
Variation in hemoglobin content is…
Anisochromia
Spherocytosis occurs when there is an _______ (INC, DEC) MCHC
Increased
Variation in RBC cell shape
Poikilocytosis
Red cell with irregular spikes: ____________
Red cell with regular scalloped short projections: _____________
Acanthocyte/Spur cell/Thorn cell
Echinocyte/Burr/Sea urchin/ Crenated cells
Describe target cell/codocyte/mexican hat cell
Peripheral rim of Hb surrounded by clear area and central hemoglobinized area
Resemble shooting target (bull’s eye)
Excessive ratio of membrane lipid to cell volume
Seen in hemoglobinopathies
Abnormal red cell that lacks central pallor
Spherocyte or bronze cells
Abnormal red cell that is elongated or has a slit-like area
Stomatocytes
mouth-like appearance
INC Na ions, DEC K ions
Cigar shaped, narrower than ovalocytes
Elliptocytes
Abnormal cells that are present on Gerbich null disease
Elliptocyte
Abnromal cell with Bipolar arrangement in hemoglobin with reduction in membrane cholesterol
Ovalocyte
egg-like or oval-shaped
Poikilocytes secondary to trauma
Schistocyte
Dacrocyte (Tear drop cell)
Pyropoikilocytes
Semilunar bodies/Half moon
Which abnormal RBC fragment at 45deg C?
Pyropoikilocytes
Abnormal RBC that fragments from prosthetic heart valves
Schistocyte /Schiztocyte
Poikilocyte that is caused by polymeration of deoxygenated Hgb
Drepanocytes / Sickle Cell Menisocytes
Red cell present on “Holy leaf formation”
Schistocyte / Schiztocyte
Rbc inclusion resulting from karyorrhexis
Howell joy bodies
Blue berry bagel appearance
Basophilic stippling / Punctuate basophilia
Rbc inclusion: Remnants of microtubules of mitotic spindle
Cabot rings
Rbc inclusion: from precipitated denatured Hgb due to oxidative injuries
Heinz bodies
Multiple heinz bodies may give a cell appearance of….
Pitted golf ball
Pappenheimer bodies are…
Unused iron deposits
Rbc inclusion: hexagonal w/ blunt ends and stain darkly
Hb C or CC Crystals
Barr of Gold / Clam Shell appearance
Rbc inclusion: Crystalline finger-like / quartzlike crystals
Hb SC crystals
Washington monument crystal
Rbc inclusion: Excessive iron overload in mitochondria of normoblast
Ringed sideroblast
Malarial inclusions:
P.malariae
P.ovale
P. vivax
P.falciparum
Ziemann’s dot
James dot
Schuffner’s dot
Maurer’s dot
Rouleaux formation is due to…..
Abnormal or INC plasma proteins
Rbc fragment in a shape of a helmet
Keratocyte
Blister cells are erythrocytes containing….
One or more vacuoles that resemble blister on skin
vacuoles may rupture producing: keratocytes or schistocytes.
Blister cells result from…
Traumatic interaction of blood vessels and circulating blood
Abnormal rbc that resemble pinched bottle
Knizocyte
