Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMA LEC PRELIM > RBC > Flashcards

RBC Flashcards

1
Q

Mature RBC size

A

6-8 micron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

less stable than those of mature cells

A

reticulocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

the skeletal system for living cell

A

tubulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

responsible for contraction and relaxation of the membrane

A

actin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Mature Red Blood Cell Membrane

A

 Soft and pliable
 Biconcave shape
 Consists of a membrane skeleton
protein lattice and lipid bilayer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Outer layer of membrane lipids

A
  • phosphatidyl choline
  • sphingomyelin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Inner layer of membrane lipids

A
  • phosphatidyl serine
  • phosphatidyl ethanolamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Membrane proteins

A
  • integral protein
  • peripheral protein
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Integral protein

A

BAG
- Band 3
- Aquaporin
- Glycophorin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Peripheral protein

A

o Actin
o Protein4.1
o Pallidin(band4.2)
o Ankyrin
o Adducin
o Tropomycin
o Tropomodulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Anion transport

A

BAnd 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Interaction with ankyrin and protein
4.2, secondarily through binding to
protein4.1

A

Band 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Imparts a negative charge to the cell

A

Glycophorin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Exchanges bicarbonate for
chloride

A

Band 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Selective pores for water transport

A

Aquaporin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Flexible,rod-likemolecule

A

spectrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

two subunit of spectrin

A

Alpha and beta spectrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

responsible for the shape of RBC

A

spectrin, ankyrin, actin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Attachment for ankyrin near C terminus

A

beta spectrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Short, uniform filaments

A

actin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Length of actin is modulated by

A

tropomyosin/tropomodulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Stabilizes actin-spectrin interactions

A

Protein 4.1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Also stabilzes interaction of spectrin with actin
* Influenced by calmodulin

A

Adducin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Promotes spectrin-actin interactions

A

ankyrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Interacts with band 3 and spectrin to achieve linkage
between bilayer and skeleton

A

ankyrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

During pressure upon RBC, spectrin molecules undergo
reversible change in conformation: some uncoiled and
extended, others compressed and folded.

A

membrane deformability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Cytoplasmic contents of RBCs include

A

potassium ions,
sodium ions, glucose, intermediate products of
glycolysis and enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Major source of the essential cellular energy

A

Embden-Meyerhof Pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Embden-Meyerhof Pathway end product

A

pyruvate and lactate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Embden meyerhof pathway glycolysis

A

Anaerobic glycolysis

31
Q

percentage of glycolysis occurs in EMP pathway

A

90%

32
Q

How EMP form ATP

A

glucose > lactic acid > form 2 ATP

33
Q

Oxidative Pathway also known as

A

Hexose monophosphate shunt
Pentose phosphate pathway

34
Q

what is the enzyme involved in hexose monophosphate shunt?

A

G6PD

35
Q

Percentage of glycolysis occurs in hexose monophosphate shunt

A

10%

36
Q

How reduced glutathione form

A

Convert NADP to NADPH then NADPH will
convert to reduced glutathione

37
Q

end product of Hexose monophosphate shunt

A

production of reduced glutathione

38
Q

Depends on Embden-Meyerhof pathway for the reduced
pyridine nucleotides that keeps hgb in a reduced state

A

methemoglobin reductase pathway

39
Q

function of methemoglobin reductase pathway

A

maintains hemoglobin iron in the ferrous state and this will then convert methemoglobin back to normal hemoglobin using methemoglobin reductase enzyme

40
Q

Important in the oxygen carrying capacity of
RBCs

A

Leubering-Rapoport Pathway

41
Q

regulates oxygen affinity of hemoglobin

A

Leubering-Rapoport Pathway

42
Q

Leubering-Rapoport pathway will generate ______ to regulate the affinity in
hemoglobin to oxygen.

A

2,3DPG (2,3 – Diphosphoglycerate)

43
Q

low 2,3 DPG therefore high hemoglobin affinity

A

shift to the left

44
Q

high 2,3 DPG therefore low hemoglobin affinity

A

shift to the right

45
Q

prevents denaturation of globin of the hemoglobin molecules by oxidation

A

oxidative pathway

46
Q

Term describing the dynamic of RBC production

A

ERYTHROKINETICS

47
Q

name given to the collection of all stages of
erythrocytes throughout the body, developing precursor in
the bm, and the circulating rbc in peripheral blood.

A

Erythron

48
Q

A hormone produced in the kidney in response to tissue
hypoxia

A

ERYTHROPOIETIN

49
Q
  • Elevated EPO levels are observed in:
A

Erythroid hyperplasia
Polycythemia
Hemorrhages
Inc RBC destruction

50
Q

– loss of a portion of the erythrocytes
membrane, accompanied by loss of cellular contents
including hemoglobin

A

Fragmentation

51
Q

passing of water into the red cell as to
ultimately burst it

A

. Osmotic lysis

52
Q

ingestion of whole red cells by
circulating monocytes or neutrophil or by fixed
macrophages of the mononuclear phagocyte system

A

Erythrophagocytosis

53
Q

complement has the
ability to attach itself to the cells and induce lysis.

A

Complement induced cytolysis

54
Q

Lysis of erythrocytes which occurs within the
circulation through the classic pathway

A

Intravascular hemolysis

55
Q

major free
hemoglobin transport protein

A

Haptoglobin

56
Q

hemoglobin in plasma will bind to

A
  • haptoglobin
  • hemoglobinemia/hemoglobinuria
  • renal tubular
57
Q

recycled into amino acids for protein synthesis

A

globin

58
Q

What will bind to transferrin that will be transported to bm

A

iron

59
Q

causes INTRAVASCULAR HEMOLYSIS

A

ABO mismatched blood transfusion
o Cold agglutinin disease (CAD)
o Paroxysmal cold hemoglobinuria
Burns
Snake bites
o Bacterial – C.perfringens sepsis
o Parasitic infection
o Mechanical heart valvles
o Paroxysmal nocturnal hemoglobinuria

60
Q

causes EXTRAVASCULAR HEMOLYSIS

A

o Bacterial/Viral infections
o Drug induced
o Autoimmune
o Microangiopathic Hemolytic Anemia
o Hemoglobinopathies
o Membrane defects
o Metabolic defects

61
Q

linkage of lipid bilayer to underlying membrane skeleton

A

band 3

62
Q

support all the content and structural integrity of the RBC

A

horizontal interaction

63
Q

support the internal and external of RBC (all the content of RBC)

A

vertical interaction

64
Q

carries MN and gerbich blood group antigen

A

Glycophorin A

65
Q

important for P. falciparum invasion and development in RBC

A

Glycophorin C, glycophorin A

66
Q

It is very rich in sialic acid which will need of RBC to become hydrophilic to enable them to circulate without adhering to other cells

A

Glycophorin

67
Q

Aquaporin also known as

A

water transporter

68
Q

Allows RBC to remain in osmotic equilibrium with extracellular fluid

A

Aquaporin

69
Q

binding site for actin filaments and protein 4.1

A

At N terminus

70
Q

augmented by protein 4.2

A

ankyrin

71
Q

deformability is an important property of red cell function influence by:

A
  • cell shape
  • cytoplasmic viscosity
  • membrane deformability and stability
72
Q

yellowish brown crystal

A

hemosiderin

73
Q

this is usually happens through phagocytosis

A

extravascular hemolysis

HEMA LEC PRELIM (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions