HEMATOPOIESIS Flashcards
is a continuous, regulated
process of blood cell production
Hematopoiesis/Hemopoiesis
Hematopoiesis includes:
- Cell Renewal – replenishment
- Proliferation – multiplication
- Differentiation – immature to immature
- Maturation
What are the two hematopoietic development?
- Prenatal/Fatal Development
- Postnatal/Adult Hematopoiesis
What are the examples of Prenatal/Fatal Development
- Mesoblastic
- Hepatic
- Myeloid
Primitive erythrocytes are found in the yolk sac arise from mesodermal cell
mesoblastic phase
chief site of mesoblastic where
hematopoiesis takes place
yolk sac
Begins around the 19th day of embryonic
development after fertilization
mesoblastic phase
Fifth month of fetal development
Medullary (Myeloid) Phase
first fully developed organ in the fetus. The major site of T cell production
Thymus
The hepatic phase of hematopoiesis begins at 5 to 7 gestational weeks
Hepatic phase
needed for oxygen transportation, not found in Adult Life
Embryonic Hemoglobin
Globin Chain Combination for Gower II
2 alpha 2 epsilon
Globin Chain Combination for Gower I
2 epsilon 2 zeta
chief site with the help of Spleen
Liver
Characterized by recognizable clusters of developing
erythroblasts, granulocytes, and monocytes colonizing
the fetal liver, thymus, spleen, placenta
Hepatic phase
The developing erythroblasts signal the beginning of
definitive hematopoiesis with a decline in primitive
hematopoiesis of the yolk sac.
Hepatic phase
Embryonic Hemoglobin is replaced by ______ and detectable ______
Hemoglobin F ; Hemoglobin A
Organs which produce B cells
Kidney, Spleen
Adult Hemoglobin
Hb A, Hb A2
Globin Chain Combination for Hb A
2 alpha 2 beta
Globin Chain Combination for Hb A2
2 alpha 2 delta
Adult hematopoietic tissue located in
→ Bone Marrow
→ Lymph Nodes
→ Spleen, Liver
→ Thymus
Hematopoietic tissue is involved in the proliferation and
maturation of blood cells.
POSTNATAL DEVELOPMENT
Organs involved in postnatal development.
A. Bone marrow – largest
B. Liver
C. Spleen
D. Lymph Nodes
E. Thymus
One of the largest organs in the body
Bone marrow
Major function of bone marrow
proliferation and production of blood cells
Hematopoietically inactive marrow
composed primarily of adipocytes and fat
cells, with undifferentiated mesenchymal
cells and macrophages.
Yellow marrow
Hematopoietically active marrow
consisting of the developing blood cells and their progenitors (flat bones of the skull, clavicle, sternum, ribs, vertebrae and pelvis
Red marrow
Immature,
undifferentiated hematopoietic cells
committed to a definite cell lineage yet to
be identified
progenitors
Production of erythrocytes, platelets, basophil, etc.
Common myeloid progenitors