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HEMA LEC PRELIM > HEMATOPOIETIC SYSTEM > Flashcards

HEMATOPOIETIC SYSTEM Flashcards

1
Q

During the normal maturation of RBC or cell, what would be the changes that will occur?

A
  • size
  • nucleus
  • cytoplasm
  • chromatin
  • granules
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2
Q

the cytoplasm of an immature
cell is usually blue or basophilic due to RNA content.

A

Loss of Basophilia

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3
Q

These granules contain some
enzymes which distinguish the myeloid stem cells from other cells

A

cytoplasmic granules

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4
Q

acidophilic or eosinophilic granules

A

red dye

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5
Q

are called basophilic
granules

A

blue dye

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6
Q

basic and acidic dye

A

Neutrophilic granules

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7
Q

special feature
of the maturation of erythrocytes cells.

A

Elaboration of Hemoglobin

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8
Q

How many series are there in the maturation of erythrocytes?

A

6 series

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9
Q

the nucleus is apparently no
longer necessary and eliminated by
nucleolysis or extursion

A

Mature stage

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10
Q

anucleated cells

A

erythrocytes

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11
Q

The immature nucleus is round or oval and the nuclear chromatin is very delicate, fine and linear and is called

A

EUCHROMATIN

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12
Q

it would give a pale blue color, uncondensed

A

EUCHROMATIN

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13
Q

As the cells matures chromatin strands
increasingly coarse and clumped

A

HETEROCHROMATIN

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14
Q

in terms of size, a mature cell is _______
than immature cells.

A

smaller

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15
Q

Enumerate the nuclear changes

A
  • Structure and Cytochemistry
  • Shape Changes
  • Reduction in cell size
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16
Q

Inclusion bodies may be found
in the cytoplasm of both erythrocytes and
leukocytes, especially in the granulocytes

A

abnormal cytoplasmic

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17
Q

this is characterized by persistent
cytoplasmic basophilia and late
hemoglobinization.

A

Abnormal Cytoplasmic Differentiation

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18
Q

Does immature cells contain hemoglobin?

A

No

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19
Q

best example for mature stage

A

erythrocyte

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20
Q

What do you call if the lobes of neutrophil is 6-10?

A

Hypersegmented neutrophils

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21
Q

What could be the reason why neutrophils has many lobes?

A
  • old cell
  • megaloblastic anemia
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22
Q

What are the example of inclusion bodies that are present in RBC

A
  • Howell-Jolly bodies,
  • Pappernheimer bodies
  • Heinz bodies
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23
Q

Hyposegmented is seen in condition
associated with

A

Pelger-Huet Anomaly ; problem with lamin B

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24
Q

less than two lobes

A

Hyposegmented neutrophils

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25
Q

types of human stem cell

A
  • Totipotential stem cells
  • Pluripotential stem cells
  • Multipotential stem cells
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26
Q

These cells are present several days after
fertilization. can develop into any cell type, except they cannot develop into a FETUS.

A

Pluripotential stem cells

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27
Q

These cells are present in the first few
hours after an ovum is fertilized. most versatile type of stem cell, can develop into any human cell type, including development from embryo into
fetus

A

Totipotential stem cells

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28
Q

These cells are derived from pluripotent
stem cells. They can be found in adults, but they are limited to specific types of cells to form tissues

A

Multipotential stem cells

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29
Q

reticulocyte can stay in the peripheral blood for how long?

A

1 day

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30
Q

reticulocyte can stay in the bone marrow for how long?

A

1-2 days

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31
Q

the first recognizable
erythroid precursor

A

rubriblast

32
Q

Granulopoiesis - they only have one way; they only differ in the matured stage

A

Basophils
Eosinophils
Neutrophils

33
Q

is a process by which erythroid
precursor cells differentiates to become mature

A

Erythropoiesis

34
Q

Other name for Pronormoblast

A

Rubriblast

35
Q

N:C ratio of Pronormoblast

A

8:1

36
Q

Other name for Basophilic Normoblast

A

Prorubricyte

37
Q

N:C ratio decreases from 8:1 to 6:1

A

Basophilic Normoblast

38
Q

globin production begins

A

Rubricyte

39
Q

begins to accumulate the
components necessary for hemoglobin
production.

A

Pronormoblast

40
Q

Detectable hemoglobin synthesis occurs, but the many cytoplasmic organelles, including ribosomes and a substantial amount of messenger ribonucleic acid

A

Basophilic Normoblast

41
Q

Late Normoblast

A

Metarubricyte

42
Q

LAST STAGE OF MITOSIS

A

Rubricyte

43
Q

The increase in the salmon-pink color of the cytoplasm reflects nearly complete
hemoglobin production

A

Metarubricyte

44
Q

First stage of maturation

A

Prorubricyte

45
Q

presence of hof

A

neutrophils Promyelocytes

46
Q

No nucleus but has mitochondria and
ribosomes

A

reticulocyte

47
Q

Last stage to synthesize hemoglobin

A

reticulocyte

48
Q

reticulocyte also known as

A

Polychromatophilic erythrocytes
Polychromatophilic macrocytes
Diffusely basophilic erythrocytes

49
Q

salmon pink-staining cell with a central
pale area.

A

erythrocytes

50
Q

Make up 0% to 3% of the nucleated cells in
the bone marrow and measure 14 to 20 mm in diameter

A

Myeloblasts

51
Q

Nucleoli are absent

A

Neutrophil metamyelocytes

52
Q

can be identified
cytochemically due to the presence of Charcot
Leyden crystal protein in their primary granules

A

Eosinophilic promyelocytes

53
Q

eosinophils have a circulating half-life of
roughly

A

18 hours

54
Q

cytoplasm is colorless and contains
large numbers of the characteristic large
blue-black granules

A

mature basophils

55
Q

have round to lobulated nuclei
with only slightly condensed chromatin.

A

immature basophils

56
Q

contain a lobulated nucleus that is
often obscured by its granules

A

mature basophils

57
Q

moderately basophilic to blue or
gray; non granular

A

monoblast

58
Q

Cleavage occurs

A

Promonocytes

59
Q

may have
small blunt pseudopods, narrow band around the
nucleus; as the cell matures the amount of
cytoplasm increases

A

Megakaryoblast (STAGE 1)

60
Q

more abundant than in previous
stage; granules begin to form in the golgi region

A

Promegarkayocytes (Stage II)

61
Q

contains
coarse clumps of granules
aggregating into little
bundles which bud off from
the periphery –plts

A

Megakaryocyte (Stage III)

62
Q

cytoplasm is light blue – purple

A

platelets

63
Q

this stage lasts more than 24 hours

A

rubriblast

64
Q

no nucleoli are present

A

rubricyte or normoblast

65
Q

first stage in color changing

A

rubricyte

66
Q

the stage in rubricyte lasts for

A

30 hours

67
Q

nucleus is completely condensed

A

orthrochromic normoblast or metarubricyte

68
Q

not capable of division due to the condensation of the chromatin

A

metarubricyte

69
Q

last stage in bone marrow before release to the blood

A

reticulocyte

70
Q

stain living cells

A

supravital stain

71
Q

earliest recognizable granulocyte precursor

A

myeloblast

72
Q

also known as juvenile cell

A

neutrophil metamyelocyte

73
Q

it is water soluble and may be dissolve if the blood film is washed too much during the staining process

A

immature basophils

74
Q

cleavage occurs

A

promonocytes

75
Q

lacelike or stringy

A

promonocytes

76
Q

would go to the sites of injury to temporarily prevent the bleeding

A

platelets

HEMA LEC PRELIM (5 decks)

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