Rational Antimicrobial Use Flashcards
True/False. Antimicrobial use promotes selection of resistance bacteria, thereby reducing their therapeutic efficacy over time.
True.
What is rational antimicrobial use?
Antimicrobial agents aimed at maximizing therapeutic efficacy while minimizing the risks associated with development of resistance.
Which drugs are critically important antibiotics for everyone?
- Fluoroquinolones
- 3rd generation cephalosporins
- Macrolides
What are examples of 3rd and 4th generation cephalosporins?
Cefovecin, cefpodoxime (small animals)
ceftiofur and cefquinome (food animals and horses)
What are examples of Fluoroquinolones?
Enrofloxacin, ciprofloxacin, marbofloxacin, etc.
Which drugs are the last resort drugs for human use?
Carbapenems
Linezolid
Vancomycin
Which drug has a narrow spectrum and is not licensed for use on animals?
Chloramphenicol
What is “shoot” regular, and which drugs are examples?
Time-dependent drugs (all beta-lactams) at regular intervals
What is “shoot” high, and which drugs are examples?
High doses for concentration-dependent drugs (fluoroquinolones and aminoglycosides)
What are two measures for control of AMR?
Control of antimicrobial use
Control of transmission
_______ refers to coordinated interventions designed to improve and measure the appropriate use of antimicrobials.
Antimicrobial Sterwardship
