Random Questions Missed Flashcards
Rasburicase MOA
convert uric acid into more soluble metabolites
rifampin, phenobarbital, and phenytoin _______CYP450 enzymes and those that does what to efficacy of warfarin?
enhance (induce), and decreases
Human tumor cells can resist chemotherapy via human mutidrug resistance (MDR1) gene; the protype product of this gene is p.glycoprotein which is a transmembrane protein that functions as?
a ATP dependent efflux pump
Normally _________ is present in intestinal and renal tubular epithelial cells and functions to eliminate foreign compounds from the body?
p. glycoprotein
immediate reversal of warfarin overdose?
fresh frozen plasma
vinka alkaloids work on what phase? also, taxans work here?
M phase
bleomycin and doxorubicin work on?
G2 phase
antimetabolites, and topoisomerase 1 and 2 inhibitors work?
S phase
nucleoside monophosphate (i.e. nucleotide) that requires only cellular kinases for activation?
cidofovir
What drugs bind to and activate vitamin D receptor; a nuclear transcription factor that causes inhibition of keratinocyte proliferation and stimulation of keratinocyte differentiation? also, used for psoriasis?
topical vitamin D analogy; like calcipoteriene( calcipotriol); calcitriol, and tacalcitol
Abciximab MOA
glycoprotein 2B/3A receptor
Clopidogrel MOA
ADP receptor (platelets)
patient with testicular cancer has PFTS consistent with restrictive lung disease; what drug cases this?
bleomycin
patient preparing for bone marrow transplantation has PFTS consistent with restrictive lung disease; what drug cases this?
busulfan
hirudin, lepirudin, and argatroban MOA
direct thrombin inhibitor
Mealtime insulin analogs (lispro, aspart, and glulisin) mimic
postprandial insulin
Which Selective estrogen receptor modulator has a side effect of endometrial hyperplasia and carcinoma?
tamoxifen
What drugs suppress GnRH and pituitary gonadotropin secretion and inhibit ovulation?
combined hormonal contraceptive
Which drug thickens cervical mucus and impairs sperm penetration?
progestin only pill or levonotgestrel IUD
Increase in estrogen activity will do what to circulating TBG levels? which causes corresponding reduction in free T4 and free T3 levels. Due to feedback control this increases total thyroid hormone levels and maintenance of normal levels of free thyroid hormone
increase
Methimazole and PTU work to inhibit what enzyme? which is responsible for iodine organification and coupling of iodotyrosines.
thyroid peroxidase
What are the 3 bile acid binding resins?
cholestyramine, colestipol, colesnvelam
What drug class could be used as mono therapy to increase triglyceride levels?
bile acid binding resins
What kind of drugs can inhibit the NE/epi mediated compensatory reactions to hypoglycemia (cholinergic symptoms are unaffected). ; also be aware of the possibly increased risk of hypoglycemia and reduction of awareness of hypoglycemia in diabetic patients?
nonselective beta blockers (propanolol, timolol, and nadolol)
What drug causes decreased renal excretion of uric acid? so this leads elevated blood levels and increased risk of gouty arthritis?
niacin
MOA : increase HDL levels?
niacin
MOA: decrease triglycerides by activating PPAR alpha
fibrates
What is due to increased soft tissue mass within the orbit and does not improve with beta blockers?
exophthalmos in Grave’s disease
