Random Questions Missed

Question 1

Rasburicase MOA

Answer 1

convert uric acid into more soluble metabolites

Question 2

rifampin, phenobarbital, and phenytoin _______CYP450 enzymes and those that does what to efficacy of warfarin?

Answer 2

enhance (induce), and decreases

Question 3

Human tumor cells can resist chemotherapy via human mutidrug resistance (MDR1) gene; the protype product of this gene is p.glycoprotein which is a transmembrane protein that functions as?

Answer 3

a ATP dependent efflux pump

Question 4

Normally _________ is present in intestinal and renal tubular epithelial cells and functions to eliminate foreign compounds from the body?

Answer 4

p. glycoprotein

Question 5

immediate reversal of warfarin overdose?

Answer 5

fresh frozen plasma

Question 6

vinka alkaloids work on what phase? also, taxans work here?

Answer 6

M phase

Question 7

bleomycin and doxorubicin work on?

Answer 7

G2 phase

Question 8

antimetabolites, and topoisomerase 1 and 2 inhibitors work?

Answer 8

S phase

Question 9

nucleoside monophosphate (i.e. nucleotide) that requires only cellular kinases for activation?

Answer 9

cidofovir

Question 10

What drugs bind to and activate vitamin D receptor; a nuclear transcription factor that causes inhibition of keratinocyte proliferation and stimulation of keratinocyte differentiation? also, used for psoriasis?

Answer 10

topical vitamin D analogy; like calcipoteriene( calcipotriol); calcitriol, and tacalcitol

Question 11

Abciximab MOA

Answer 11

glycoprotein 2B/3A receptor

Question 12

Clopidogrel MOA

Answer 12

ADP receptor (platelets)

Question 13

patient with testicular cancer has PFTS consistent with restrictive lung disease; what drug cases this?

Answer 13

bleomycin

Question 14

patient preparing for bone marrow transplantation has PFTS consistent with restrictive lung disease; what drug cases this?

Answer 14

busulfan

Question 15

hirudin, lepirudin, and argatroban MOA

Answer 15

direct thrombin inhibitor

Question 16

Mealtime insulin analogs (lispro, aspart, and glulisin) mimic

Answer 16

postprandial insulin

Question 17

Which Selective estrogen receptor modulator has a side effect of endometrial hyperplasia and carcinoma?

Answer 17

tamoxifen

Question 18

What drugs suppress GnRH and pituitary gonadotropin secretion and inhibit ovulation?

Answer 18

combined hormonal contraceptive

Question 19

Which drug thickens cervical mucus and impairs sperm penetration?

Answer 19

progestin only pill or levonotgestrel IUD

Question 20

Increase in estrogen activity will do what to circulating TBG levels? which causes corresponding reduction in free T4 and free T3 levels. Due to feedback control this increases total thyroid hormone levels and maintenance of normal levels of free thyroid hormone

Answer 20

increase

Question 21

Methimazole and PTU work to inhibit what enzyme? which is responsible for iodine organification and coupling of iodotyrosines.

Answer 21

thyroid peroxidase

Question 22

What are the 3 bile acid binding resins?

Answer 22

cholestyramine, colestipol, colesnvelam

Question 23

What drug class could be used as mono therapy to increase triglyceride levels?

Answer 23

bile acid binding resins

Question 24

What kind of drugs can inhibit the NE/epi mediated compensatory reactions to hypoglycemia (cholinergic symptoms are unaffected). ; also be aware of the possibly increased risk of hypoglycemia and reduction of awareness of hypoglycemia in diabetic patients?

Answer 24

nonselective beta blockers (propanolol, timolol, and nadolol)

Question 25

What drug causes decreased renal excretion of uric acid? so this leads elevated blood levels and increased risk of gouty arthritis?

Answer 25

niacin

Question 26

MOA : increase HDL levels?

Answer 26

niacin

Question 27

MOA: decrease triglycerides by activating PPAR alpha

Answer 27

fibrates

Question 28

What is due to increased soft tissue mass within the orbit and does not improve with beta blockers?

Answer 28

exophthalmos in Grave’s disease