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Pharm > MSK/DERM > Flashcards

MSK/DERM Flashcards

1
Q

NSAID that irreversibly inhibits cyclooxygenase (both COX-1 and COX-2)

A

Aspirin

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2
Q 
Low dose (< 300 mg/day): 􀁲 platelet aggregation. Intermediate dose (300–2400 mg/day): antipyretic
and analgesic. High dose (2400–4000 mg/day): anti-inflammatory.
A

Aspirin

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3
Q

Gastric ulceration, tinnitus (CN VIII). Chronic use can lead to acute renal failure, interstitial
nephritis, GI bleeding. Risk of Reye syndrome in children treated with aspirin for viral infection.

A

ASA

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4
Q

Causes respiratory alkalosis early, but transitions to mixed metabolic acidosis-respiratory alkalosis.

A

ASA

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5
Q

Reversibly inhibits specifically the cyclooxygenase (COX) isoform 2,

A

Celecoxib

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6
Q

helps maintain gastric mucosa.

A

Cox 1

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7
Q

found in

inflammatory cells and vascular endothelium and mediates inflammation and pain;

A

Cox 2

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8
Q

spares

COX-1, which helps maintain gastric mucosa.

A

Celecoxib

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9
Q

Spares platelet function as TXA2 production is dependent on COX-1.

A

Celecoxib

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10
Q

Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac, meloxicam, piroxicam.

A

NSAIDS

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11
Q

Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis.

A

NSAIDS

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12
Q

Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.

A

NSAIDS

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13
Q

inhibit leukotriene receptor

A

montelukast, zafirlukast

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14
Q

Reversibly inhibits cyclooxygenase, mostly in the CNS

A

acetaminophen

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15
Q

inhibits chemotaxis, phagocytosis and degranulation. Also reduces formation of LTB4

A

colchicine

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16
Q

inhibit leukotriene synthesis

A

zileuton

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17
Q

inhibit phospholipase A 2

A

glucocorticoids (corticosteroids)

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18
Q

increase bronchial tone

A

leukotrienes (LTC4, LTD4, LTE4)

19
Q

increase neutrophil chemotaxis

A

LTB4

20
Q

decrease platelet aggregation

A

PGI2

21
Q

decrease vascular tone

A

prostacyclin, prostaglandin

22
Q

increase uterine tone

A

PGE2, PGF2A

23
Q

Increase platelet aggregation and increase vascular tone

A

TXA2

24
Q

Antipyretic, analgesic, but not anti-inflammatory. Used instead of aspirin to avoid Reye syndrome
in children with viral infection.

A

acetaminophen

25
Q

N-acetylcysteine is antidote—regenerates glutathione

A

acetaminophen overdose

26
Q

Reversibly inhibits dihydroorotate dehydrogenase, preventing pyrimidine synthesis. Suppresses
T-cell proliferation

A

leflunomide

27
Q

Pyrophosphate analogs; bind hydroxyapatite in bone, inhibiting osteoclast activity.

A

Bisphosphonates

28
Q

Alendronate, ibandronate, risedronate, zoledronate.

A

Bisphosphonates

29
Q

Recombinant PTH analog given subcutaneously daily. increase􀁱 osteoblastic activity

A

Teriparatide

30
Q

Recombinant uricase that catalyzes metabolism of uric acid to allantoin.

A

rasburicase

31
Q

All____________ predispose to infection, including reactivation of latent TB, since TNF is
important in granuloma formation and stabilization

A

TNF-α inhibitors

32
Q 
Fusion protein (receptor for TNF-α + IgG1 Fc),
produced by recombinant DNA.
A

entanercept

33
Q

anti-TNF alpha monoclonal Antibody

A

infliximab, adalimumab

34
Q

Competitive inhibitor of xanthine oxidase.
decrease􀁲 conversion of hypoxanthine and xanthine to
urate.

A

allopurinol

35
Q

Inhibits xanthine oxidase.

A

febuxostat

36
Q

Recombinant uricase that catalyzes metabolism
of uric acid to allantoin (a more water-soluble
product).

A

pegloticase

37
Q

Inhibits reabsorption of uric acid in proximal
convoluted tubule (also inhibits secretion of
penicillin). Can precipitate uric acid calculi.

A

probenecid

38
Q

Naproxen, indomethacin.
Do not give salicylates; all but the highest
doses depress uric acid clearance. Even high
doses (5–6 g/day) have only minor uricosuric
activity.

A

NSAIDS

39
Q

acute gout drugs

A

NSAIDS, glucocorticoids, colchicine

40
Q

Binds and stabilizes tubulin to inhibit
microtubule polymerization, impairing
neutrophil chemotaxis and degranulation.
Acute and prophylactic value. GI side effects.

A

colchicine

41
Q

PABA esters are used on what type of UV radiation?

A

UVB only

42
Q

What is a major cause of sunburns?

A

UVB

43
Q

what causes skin photo agin, photo carcinogenesis, UVR induced immunosuppression, histologic skin damage?

A

UVB

Pharm (9 decks)

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