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Pharm > Psych > Flashcards

Psych Flashcards

1
Q

ADHD

A

Stimulants (methylphenidate, amphetamines)

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2
Q

Alcohol withdrawal

A

Benzodiazepines (eg, chlordiazepoxide,

lorazepam, diazepam)

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3
Q

Bipolar disorder

A

Lithium, valproic acid, atypical antipsychotics

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4
Q

Bulimia nervosa

A

SSRIs

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5
Q

Depression

A

SSRIs

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6
Q

Generalized anxiety disorder

A

SSRIs, SNRIs

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7
Q

Obsessive-compulsive disorder

A

SSRIs, venlafaxine, clomipramine

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8
Q

Panic disorder

A

SSRIs, venlafaxine, benzodiazepines

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9
Q

PTSD

A

SSRIs, venlafaxine

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10
Q

Schizophrenia

A

Atypical antipsychotics

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11
Q

Social anxiety disorder

A

SSRIs, venlafaxine

Performance only: β-blockers, benzodiazepines

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12
Q

Tourette syndrome

A

Antipsychotics (eg, fluphenazine, pimozide),

tetrabenazine

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13
Q

CNS stimulants MOA

A

increase􀁱 catecholamines in the synaptic cleft, especially norepinephrine and dopamine.

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14
Q

Neuroleptic malignant syndrome (NMS)

A

—
rigidity, myoglobinuria, autonomic instability,
hyperpyrexia.

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15
Q

MOA:
block dopamine D2
receptors (increase􀁱 [cAMP]).

A

Antipsychotics

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16
Q

Haloperidol, trifluoperazine, fluphenazine, thioridazine, chlorpromazine (haloperidol + “-azines”).

A

antipsychotics

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17
Q

High potency: Trifluoperazine, Fluphenazine,

Haloperidol (Try to Fly High)—cause:

A

neurologic
side effects (eg, extrapyramidal symptoms
[EPS]).

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18
Q

Aripiprazole, asenapine, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine,
risperidone, ziprasidone.

A

atypical antipsychotics

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19
Q

Side effect of clozapine

A

agranulocytosis (monitor WBC

weekly).

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20
Q

SE of -pines

A 
metabolic syndrome (weight gain,
diabetes, hyperlipidemia).
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21
Q

SE of risperidone

A

hyperprolactinemia (amenorrhea,

galactorrhea, gynecomastia).

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22
Q

Se of olanzapine

A

obesity: monitor the lipid panel and fasting glucose

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23
Q

buspirone MOA:

A

Stimulates 5-HT1A receptors..

Takes 1–2
weeks to take effect. Does not interact with
alcohol (vs barbiturates, benzodiazepines).

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24
Q

SSRI MOA:

A

5-HT–specific reuptake inhibitors.

25
Q

Fluoxetine, paroxetine, sertraline, citalopram

A

SSRI

26
Q

MC SE of SSRI

A

sexual dysfunction

27
Q

Venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, milnacipran

A

SNRI

28
Q

SNRI MOA

A

Inhibit 5-HT and norepinephrine reuptake

29
Q

MC SE of SNRI

A

increase blood pressure

30
Q

Serotonin Syndrome

A

Can occur with any drug that increases 5-HT (eg, MAO inhibitors, SNRIs, TCAs).

Characterized by
3 A’s: neuromuscular Activity (clonus, hyperreflexia, hypertonia, tremor, seizure), Autonomic
stimulation (hyperthermia, diaphoresis, diarrhea), and Agitation.

31
Q

Amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine

A

TCAs

32
Q

TCAs MOA:

A

Block reuptake of norepinephrine and 5-HT.

33
Q

What can happen with TCAs?

A

Tri-C’s: Convulsions, Coma, Cardiotoxicity (arrhythmia due to Na+ channel inhibition);
also respiratory depression, hyperpyrexia.

34
Q

Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline

A

MAO inhibitors

35
Q

MAO inhibitor MOA

A

Nonselective MAO inhibition 􀁱 increase levels of amine neurotransmitters (norepinephrine, 5-HT,
dopamine).

36
Q

Atypical depression= mood reactivity, leaden paralysis (heavy arms/legs), rejection sensitivity (get butt hurt), increased sleep and appetite

A

MAO inhibitor used

37
Q

Contraindicated with SSRIs, TCAs, St. John’s wort,

meperidine, dextromethorphan to prevent?

A

serotonin syndrome

38
Q

bupropion MOA

A

􀁱increase norepinephrine and dopamine

39
Q

Mirtazapine MOA:

A

α2-antagonist (􀁱 release of NE and 5-HT), potent 5-HT2 and 5-HT3 receptor antagonist and H1
antagonist.

40
Q

Trazodone MOA

A

Primarily blocks 5-HT2, α1-adrenergic, and H1 receptors

41
Q

Varenicline MOA

A

Nicotinic ACh receptor partial agonist.

42
Q

MC toxicity with bupropion?

A

seizures in anorexic/bulimic patients

43
Q

MC toxicity with mirtazapine?

A

increase appetite and weight gain. Give to old ladies that are depressed and won’t eat or give to those that are depressed but not sleeping well ( due to sedation effects)

44
Q

MC SE of trazadone?

A

priapism

45
Q

MC SE of varenicline?

A

sleep disturbances

46
Q

1st line treatment for major depressive disorder that does not cause sexual dysfunction

A

bupropion

47
Q

MAO type B inhibitor that is given to prevent MPTP associated parkinsoniam type symptoms

A

Selegiline

48
Q

used to treat delirium

A

Haloperidol or other low dose antipsychotic

49
Q

All antidepressants carry the risk of inducing what? in susceptible patients.

A

mania

50
Q

What drug is used in treatment resistant schizophrenia?

A

clozapine

51
Q

TCA’s inhibit _______channel conduction, slowing down myocardial depolarization and leading to cardiac arrhythmias.

A

Sodium

52
Q

What is the MCC of death in patients with TCA overdose?

A

cardiac arrhythmias

53
Q

Nonbenzodiazepine anxiolytic used to treat generalized anxiety disorder that has a slow onset of action, lacks muscle relaxant, or anticonvulsant properties, and carries no risk of dependence

A

buspirone

54
Q

patient has depression, fatigue, hypersomnia, vivid dreams. What is this patient withdrawing from?

A

cocaine

55
Q

Left side frontal lobe lesions are associated with?

A

apathy and depression

56
Q

right sided frontal lobe lesions are associated with?

A

disinhibited behavior

57
Q

Methadone is great for treating opioid abuse because it has?

A

has a long half life

58
Q

Full mu-opioid receptor agonist to control chronic pain and in opioid withdrawal and maintenance treatment of addiction?

A

methadone

Pharm (9 decks)

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